PhD Position – Mechanisms of Glutamate Transporter Dysfunction in Neurological Diseases
vor 2 Monaten
Your Job:
The PhD project focuses on a family of glutamate transporters – excitatory amino acid transporters – that is responsible for synaptic glutamate homeostasis in the mammalian brain. Mutations in genes encoding these transporters cause genetic forms of epilepsy and episodic ataxia. We are interested in understanding how these mutations modify transport functions. The project is based on a combination of molecular dynamics simulations and experimental techniques (solid-supported membrane electrophysiology, fluorescence spectroscopy), with the aim to understand transproter dysfunction at atomic resolution.
Your job will include taks in the following areas:
Electrophysiology (Solid Supported Membrane Based Electrophysiology)
Molecular dynamics simulations, free energy calculations, machine learning/deep learning, Markov State Models, docking
Your Profile:
Master degree in the field of Biology/Physics/Chemistry or relatedHigh motivation and interest and/or experience in biophysics and biochemistry
Knowledge of at least one programing language required
Social competence and good communication skills for collaborative work in and with interdisciplinary teams
Ability to communicate in English
Our Offer:
We work on the very latest issues that impact our society and are offering you the chance to actively help in shaping the change We offer ideal conditions for you to complete your doctoral degree:
Opportunity to get expertise in state-of art techniques and strategies in the field of molecular biology, fluorescence microscopy, fluorescence lifetime imaging, optogenetics, neuronal cell culture; access to word-class supercomputing facilities
Possible membership in the International Helmholtz Research School of Biophysics and Soft Matter that provides a complementary research training at the interfaces of biology, chemistry, and physics, as well as transferable skills courses
We will provide continuous scientific mentoring and discussions by the your scientific advisor
The doctoral degree will be awarded by the Heinrich Heine University, Düsseldorf
Outstanding scientific and technical infrastructure – ideal conditions for successfully completing a doctoral degree
Information on employment as a PhD student at Forschungszentrum Jülich can be found here
A large research campus with green spaces, offering the best possible means for networking with colleagues and pursuing sports alongside work
Further development of your personal strengths, through an extensive range of training courses; a structured program of continuing education and networking opportunities specifically for doctoral researchers via JuDocS, the Jülich Center for Doctoral Researchers and Supervisors:
Targeted services for international employees, through our International Advisory Service
The position is for a fixed term of 3 years, with possible long-term prospects. Pay in line with 50% of pay group 13 of the Collective Agreement for the Public Service (TVöD-Bund) and additionally 60 % of a monthly salary as special payment ("Christmas bonus").
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