Doctoral Researcher in Functional Omics
vor 3 Wochen
Position Overview
We are seeking motivated and driven individuals who are passionate about exploring the functional omics related to ageing and age-associated illnesses as part of their doctoral studies.
The successful candidate will join the Population Health Sciences team, directed by Prof Dr Monique M B Breteler, at the German Center for Neurodegenerative Diseases (DZNE) in Bonn. Our research focuses on understanding the causes and biomarkers of both normal and pathological mental and physical health, particularly concerning neurodegenerative diseases and the ageing process. Our work is primarily anchored in the Rhineland Study, a longitudinal cohort investigation that prioritizes comprehensive phenotyping. Currently, the study encompasses over participants at baseline, with follow-up data already collected from nearly 5000 participants, and ongoing data acquisition. The available clinical information includes extensive structural and functional brain imaging, cognitive and neurological evaluations, cardiovascular and anthropometric measurements, sensory system assessments, medical history, and medication usage. Additionally, we possess detailed exposome data, which includes insights into physical activity, dietary habits, and exposure to environmental toxins and temperature variations. Notably, we have rich multi-omics datasets, both from baseline and follow-up, including genomic and epigenomic data (miRNA sequencing, DNA methylation), transcriptomics, metabolomics, lipidomics, and proteomics.
Key Responsibilities
- Integrate various layers of OMICS data (both cross-sectional and longitudinal) to address biological inquiries related to health outcomes, with a specific emphasis on neurodegeneration.
- Participate in and oversee data collection and processing activities.
- Conduct data analysis and prepare manuscripts for submission to peer-reviewed journals.
- Engage actively in national and international conferences.
Qualifications
- Outstanding master's degree in bioinformatics, epidemiology, biomedical sciences, or related fields.
- Demonstrated interest in quantitative research and strong analytical capabilities.
- Initial experience in analyzing high-throughput sequencing data (e.g., RNASeq) and performing quality control for such datasets is advantageous, as is familiarity with epidemiological research or large-scale clinical studies.
- Basic programming skills (preferably in R).
- Exceptional analytical and problem-solving abilities.
- Fluency in spoken and written English is essential.
- A collaborative spirit and enjoyment of working within an interdisciplinary and international team.
What We Offer
- An engaging and challenging role at the forefront of health research.
- Collaboration within a highly interdisciplinary and international team addressing critical health challenges related to ageing.
- Access to excellent scientific infrastructure with state-of-the-art research and computational facilities.
- Active support for the individual development of our employees.
- Employment terms, remuneration, and social benefits in accordance with the Public Sector Collective Agreement.
The PhD position will be integrated into the Bonn International Graduate School of Clinical and Population Science, with additional training in epidemiological, statistical, and computational methods provided as necessary. The initial duration of the position is three years, with the possibility of extension.
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