Polymer Membranes for The Incorporation of Nanopores

vor 2 Monaten

Freiburg, Deutschland University of Freiburg, Institut of Physics Vollzeit

**Polymer membranes for the incorporation of nanopores**:

- Réf
- **ABG-115889**
- Sujet de Thèse- 18/07/2023- Contrat doctoral- University of Freiburg, Institut of Physics- Lieu de travail- Freiburg - Allemagne- Intitulé du sujet- Polymer membranes for the incorporation of nanopores- Champs scientifiques- Physique
- Matériaux
- Mots clés- model membran, biological nanopore**Description du sujet**:
In the framework of the interdisciplinary cluster Nanodiag, the Polymer Physics group will investigate and optimize model membranes built from block copolymers or lipo-polymers for an innovative nanopore technology.

Biological nanopores can be produced from pore-forming proteins which insert into a lipid membrane and organise themselves to create a nanometre-sized channel across the membrane. These nanopores allow transport of ions and (bio)-molecules through the membrane. In biological systems, such nanopore channels regulate the transport of ions and molecules in and out of cells.

Embedded in the electrically insulating membrane, which is suspended in aqueous solution, such a nanopore can be employed as a single molecule detector which even can discriminate between different species. When voltage is applied across such a detector-membrane, a current of ions flows through the pore. The lengths and diameters of biological pores are commensurate with molecular dimensions and therefore the ionic current is blocked when a molecule is translocating through the pore. Both the duration of the blockade and the value of the residual current provide information about the interaction between the translocating species and the pore and can therefore be used to identify individual molecules.

**Prise de fonction**:

- 15/08/2023**Nature du financement**:

- Contrat doctoral**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- University of Freiburg, Institut of PhysicsWe offer an exciting field of multidisciplinary research of societal relevance, advanced and unique experimental tools as well as intensive supervision, embedded in a dynamic international team. The Experimental Polymer Physics group provides its infrastructure and know-how for the work on the PhD project.

**Site web**:
**Intitulé du doctorat**:

- Doctorat de Physique**Pays d'obtention du doctorat**:

- Allemagne**Etablissement délivrant le doctorat**:

- University of FreiburgWe are looking for a highly motivated PhD student who has a master degree in physics, chemistry, nanoscience or another related field. Experimental skills and a solid background in physics and chemistry of macromolecules are required (can be partially aquired during the doctoral studies). However, even more important is the capability to work in a multidisciplinary research team and to acquire all relevant competencies which are needed to solve underlying physical and chemical problems related to achieving suitable membrane systems for an innovative nanopore technology.- 31/07/2023

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