PhD Opportunity in Ion Mobility Research

vor 2 Monaten

Bremen, Bremen, Deutschland Bruker Vollzeit

Overview

Bruker is recognized as a leading provider of analytical instrumentation, delivering a wide array of advanced solutions across various research and development sectors. Our instruments are meticulously designed to enhance product safety, expedite market readiness, and assist industries in improving quality of life. With a legacy of 60 years in driving innovation, we employ over 6,200 professionals globally, operating from more than 90 locations.

Within Bruker R&D, our team comprises distinguished physicists, chemists, and data scientists dedicated to advancing mass spectrometry technologies that reveal fundamental properties of molecular systems. We collaborate extensively with both industrial partners and academic institutions, actively engaging in cutting-edge research. Our commitment to reproducible and transparent results is matched by our support for open-source software initiatives.

The MobiliTraIN initiative is a Marie Sklodowska-Curie Action Doctoral Network focused on enhancing the fundamental understanding of ion mobility high-resolution mass spectrometry (IM-HRMS). This program aims to provide reference materials and standardization guidelines, develop advanced methodologies for IM-HRMS applications in biopharmaceutical development, biological omics research, and non-target contaminant screening, while also laying the groundwork for industrial adoption of IM-HRMS through the training of 13 doctoral candidates.

This network unites some of the most innovative researchers in the fields of ion mobility and mass spectrometry, covering a diverse range of applications from biomedicine to environmental science. It consists of various academic and industrial partners across Europe, fostering close collaboration through joint symposia and training workshops. This robust international scientific framework, combined with direct interactions between academia and industry, offers an ideal environment for the personal and scientific growth of emerging researchers.

Key Offerings

  • Comprehensive scientific training within an EU doctoral program.
  • Active participation in a high-visibility research project.
  • Opportunities to engage in specialized international training courses, workshops, and conferences.
  • Possibility of research visits to renowned laboratories across Europe.
  • A prestigious three-year MSCA Fellowship.
  • Experience in a dynamic international R&D setting with a leading mass spectrometry vendor.
  • Hands-on experience in integrating fundamental research with instrument development.
  • Competitive salary for PhD candidates.
  • Annual travel allowance for research internships and attendance at international conferences and workshops.
  • Annual family allowance (if applicable).

Responsibilities

The PhD candidate will be employed by Bruker Daltonics GmbH & Co. KG and will be enrolled in the PhD program at Jena University Hospital. Utilizing state-of-the-art instrumentation, the candidate will explore fundamental characteristics of tandem ion mobility spectrometry (TIMS) devices. Working within an interdisciplinary research and prototyping team at Bruker, the candidate will collaborate with various university research labs, applying gained insights to develop novel workflows relevant to biomedicine and interpret corresponding results.

Specific responsibilities include:

  • Identifying, quantifying, and managing the impact of ion translational temperature on internal temperatures and potential fragmentation across different TIMS configurations.
  • Developing and demonstrating a first-order CCS determination, comparable to established techniques on drift tube IMS instruments.
  • Translating in-depth understanding of TIMS technology to biomedical investigations across the doctoral network.
  • Contributing to a standardized approach for evaluating and comparing fundamental physical properties and outcomes using various ion mobility spectrometry techniques.

Qualifications

  • Master's degree or equivalent in Physics, Physical Chemistry, or a related field.
  • Experience in one or more of the following areas: Ion mobility spectrometry, Mass spectrometry, Ion optics and physics, Python programming, Gas phase instrument development.
  • Strong analytical, logical, and innovative thinking skills.
  • Effective communication skills and a collaborative mindset.
  • Initial experience in preparing and writing scientific publications.
  • Proficient in scientific English (oral and written).
  • Fluency in German is advantageous.

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