Phd Student in Early Detection of Liver Cancer

vor 2 Wochen

Heidelberg, Deutschland Deutsches Krebsforschungszentrum Vollzeit

**Position**:PhD Student in Early Detection of Liver Cancer - The Role of Extracellular Matrix Proteins**

**Department**: Systems Biology of Signal Transduction

**Code number**:2023-0157

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

**Job description**:
Liver cancer with its predominant form hepatocellular carcinoma (HCC) is expected to rise due to the dramatic increase in obesity, which can result in chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD). NAFLD can progress to liver fibrosis/cirrhosis and patients with cirrhosis have an elevated risk to develop HCC. Therefore, means for early detection of cancer-promoting alterations in liver cirrhosis are urgently needed. The aim is to establish biomarker patterns and, in collaboration with theoretical partners, to utilize a mathematical modelling approach for early identification of patients with a high-risk of liver cancer. Since fibrosis and cirrhosis are characterized by major alterations in the composition of the extracellular matrix (ECM), the detection of liver-derived ECM proteins in the plasma as indicators for the remodeling of the ECM in the liver towards a cancer-promoting microenvironment is highly promising.

**Requirements**:
**We offer**:

- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School

**Important notice**:
**Earliest Possible Start Date**: as soon as possible

**Duration**: The position is limited to 3 years with the possibility of prolongation.

**Application Deadline**:01.06.2023

**Contact**:
Prof. Dr. Ursula Klingmüller
Phone +49 (0)6221/42-4481

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

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