Structural Biology Researcher

vor 23 Stunden

Heidelberg, Baden-Württemberg, Deutschland Embl-Ebi Vollzeit
Research Project Overview

The successful candidate will contribute to a cutting-edge experimental research project focused on the structure-function analysis of chromatin in archaea. The goal is to understand how eukaryotes evolved histone tails and tail-based regulatory mechanisms from an archaeal ancestor.

Key Responsibilities
  • Design and execute experiments to investigate the structural and functional effects of merging tail-less histones with eukaryotic or Asgard histone tails in vitro and in vivo.
  • Conduct cryo-EM single particle analysis of nucleosomes, FIB-milling of archaeal cells, and cryo electron tomography (cryo-ET) and subtomogram averaging of chromatin fibres.
  • Collaborate with the laboratory of Naomichi Takemata (Kyoto University) and engage in regular communication and scientific exchange with collaborators.
Requirements
  • PhD in structural biology, molecular biology, biochemistry, or related disciplines.
  • Experience in cryo-EM/cryo-ET data acquisition and processing.
  • Experience in biochemistry (protein expression & purification, DNA-protein complex characterization).
  • Confidence in working via command line.
  • Strong interest in the research topic, high motivation and commitment.
  • Ability to work independently and creatively, in an international team with a highly collaborative atmosphere.
  • Excellent communication and presentation skills, fluency in English.
Desirable Skills
  • Experience in microbiology and handling of anaerobic microorganisms.
  • Basic programming skills.
  • Familiarity with HPC computing.

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