Phd Position

The group for neurogenomics and translational myology of Prof.Dr.Sebahattin Cirak, who is Section Head of Pediatric Neurology and Metabolics at University Ulm is looking for- PhD position (f/m/d) in translational biochemistry/biophysics with focus on neurogenetic disorders- The University Hospital Ulm and its employees stand for a modern and high quality patient care, excellent university research and medical education focused on the future as well as apprenticeships in attractive professional fields. The requirements for this are qualified and committed employees.- Are you an aspiring scientist passionate about transcending the traditional boundaries of medicine and natural sciences? We invite Ph.D. students to join our innovative and dynamic research team, where we are revolutionizing the approach to pediatric neurogenetic disorders and muscular dystrophies.
- The position is open immediately in the research group for neurogenomics and translational myology of of Prof.Dr.Sebahattin Cirak, who is Section Head of Pediatric Neurology and Metabolics at University Ulm.
- Prof. Dr. Sebahattin Cirak, a former DFG Emmy Noether Group leader, a qualified chemist and experienced physician-scientist in the field of neurogenetics and muscular dystrophy is seeking visionary and enthusiastic students who are driven to achieve excellence and make impact in the molecular medicine.
- The research laboratory is located within the large pediatric research center of the Department of Pediatrics and Adolescent Medicine (Direktor: Prof. Dr. K.M. Debatin).
- Join our dynamic research group within the German Center for Child and Adolescent Health (DZKJ), an innovative hub currently being established as the youngest German Center for Health Research. Explore an exciting career opportunity on the leading edge of pediatric research in Germany, where your contributions can make a lasting impact
- **Your project**:
Our Vision: Our team is dedicated to using cutting-edge methodologies and technical innovations to tackle longstanding challenges in medical science. We believe in the power of interdisciplinary collaboration to drive forward groundbreaking discoveries.
- Research Focus: Our primary goal is to unravel the molecular mechanisms underlying pediatric neurogenetic disorders and muscular dystrophies. By understanding these mechanisms at a fundamental level, we aim to pave the way for personalized treatment strategies.
- Methodological Excellence: Our approach involves the expression of recombinant mutant proteins, followed by rigorous biochemical and biophysical characterization. This process is crucial for understanding disease mechanisms at the molecular level. Additionally, we incorporate advanced in-silico methods, including molecular modeling, to complement our experimental work.
- Transdisciplinary Approach: Our research ethos is firmly rooted in transdisciplinarity. We seek to integrate diverse scientific perspectives to develop and refine personalized treatment approaches. This includes the exploration of suitable chemical chaperones and other novel therapeutic avenues.
- Innovation in Validation: We leverage the latest in genomics technology, employing patient samples and in-vitro models for further validation of our findings. This approach ensures that our research is not only pioneering but also grounded in real-world applicability.
- Join Us: As a Ph.D. student in our team, you will be at the forefront of scientific innovation, working alongside leading experts in the field. You will have the opportunity to contribute to research that has the potential to transform the lives of those affected by these challenging disorders.
- Your Role: You will engage in cutting-edge research, develop your expertise in advanced scientific techniques, and collaborate with a network of renowned scientists and researchers. Your work will be instrumental in advancing our understanding and treatment of pediatric neurogenetic disorders and muscular dystrophies.
- You will be part of a graduate school for PhD Students within the University Ulm.
- Take the First Step: If you are ready to embark on a challenging yet rewarding scientific journey, we encourage you to apply. Join us in our quest to break new ground and make a lasting impact in the field of medical science.**Your responsibilities will include**:

- Proteomics techniques for biomarker discovery and understanding of pathological pathways
- Expression and Characterization of recombinant wild-type and mutant proteins by biophysical methods
- Determination of the exact biochemical function of these proteins and screening for chemical chaperones stabilizing mutant proteins
- Analysing multi-omics data including genomic sequences aiming to discover novel disease causing mutations
- Working in collaboration with an international team under supervision and leadership of the PI
- Publishing impactful original research papers

**Our offer**:- **Minimum qualifications**:

- Masters degree or