PhD Student Biology, Chemistry

Vor 3 Tagen

Halle Saale, Deutschland Martin-Luther-Universität Halle-Wittenberg Vollzeit

The Medical Faculty of the Martin Luther University Halle-Wittenberg invites applications for seven positions within the mikroPank research consortium. This interdisciplinary initiative is dedicated to developing preclinical, patient-specific models to advance personalized treatments for pancreatic cancer patients.

Research Assistant / PhD Student (m-f-d) (E 13, 65 %) We are hiring:
  • Three PhD students (E13, 65%), reference number: 7-242/24-D

All positions are available immediately and are temporary, until December 31, 2027.

About the mikroPank consortium:

The consortium is deticated to creating 3D tumor models from primary, patient-derived tumor cells and components of the tumor microenvironment, such as fibroblasts, adipocytes, and immune cells. These models replicate the patient-s tumor in-vitro to study mechanisms of drug resistance using advanced technologies, including single-cell RNA sequencing (scRNA-seq) and CRISPR-based genome editing. By integrating natural sciences and clinical expertise, the consortium aims to advance research towards innovative, personalized therapies for pancreatic cancer patients.

Work Tasks:
  • Cultivation of pancreatic tumor organoids and cells of the tumor microenvironment
  • Single-cell RNA sequencing (scRNA-seq)
  • Genetic manipulation of cells using CRISPR
  • Independent project management
  • Participation in national and international collaborations
  • Opportunity for own scientific qualification
Requirements:
  • Completed scientific university degree in the field of life sciences (Master)
  • Experience with cell culture techniques, ideally experience in the culture of pan-creatic tumor organoids
  • Knowledge of lentiviral transduction
  • Practical experience with single-cell RNA sequencing (scRNA-seq)
  • Programming experience in R is an advantage
  • Scientific processing, presentation and publication of achieved results
  • Very good written and spoken English language skills
  • Analytical and problem-oriented thinking
  • Structured and thorough way of working
  • Ability to work in a team
What We Offer:
  • Collaborative research environment with communication in English
  • Access to state-of-the-art equipment, facilities and resources
  • Opportunities for national and international collaborations and conference visits

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