Aktuelle Jobs im Zusammenhang mit Student (M/w/d) for a Master Thesis in The Core - Duesseldorf - IUF - Leibniz-Institut für umweltmedizinische Forschung GmbH
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Master Thesis
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Master Thesis
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Master Thesis
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Master Thesis
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Master Thesis
vor 2 Stunden
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Master Thesis
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Master Thesis
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Working Student
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Master Thesis
vor 2 Wochen
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Working Student
vor 22 Stunden
Duesseldorf, Deutschland C&A VollzeitYou say what you think and have clear principles? Then you are a perfect fit for us. C&A makes fashion for everyone, always thinking about future generations and the environment. We like to take unusual paths and look forward to your ideas, concepts and analyses. **Your responsibilities at C&A** - Assistance in proofreading and optimization of product...
Student (M/w/d) for a Master Thesis in The Core
vor 3 Wochen
The core unit “Genome Engineering and Model Development (GEMD)” led by Dr. Andrea Rossi is looking for a student (f/m/d) for a master thesis with the title: On-Target CRISPR/Cas9 Activity - Challenges in Accurate and Predictive Genome Editing.
**The project**:
CRISPR/Cas9 has revolutionized genome engineering for both research and translational medicine. As we push the boundaries of this ground-breaking technology, it is essential to address potential challenges. CRISPR/Cas9 technology cannot guarantee perfect accuracy and predictability of genome editing end results. One of the major challenges occurs due to error-prone repairs of CRISPR/Cas9-induced DNA double-strand break lesions that may entail unanticipated large genomic modifications within the CRISPR/Cas9 on-target site, which could potentially lead to deleterious outcomes. However, the extent of this issue remains unclear, and it has not yet been determined whether this phenomenon is cell-specific or reagent-specific.
The aim of this thesis is to describe a bulletproof assessment of potential on-target effects that might occur due to respective mechanisms. Therefore, a CRISPR-screen on induced pluripotent stem cells (iPSCs) and established cell lines will be conducted. The importance of iPSCs in translational medicine underpins the importance of assessing potential adverse effects that may result from inaccurate editing events. Therefore, the project requires thorough experimental planning, the conduction of cutting-edge technology in genome editing, including high-throughput NGS and digital PCR methods.
**Your profile**:
Our working group is looking for a motivated student with a high level of commitment and team spirit. The applicant should have a completed bachelor’s degree in life sciences or biology. If you are passionate about pushing the frontiers of genome engineering, exploring cutting-edge techniques, and addressing critical questions in the field, we invite you to join our team. As part of our team, you will have the opportunity to contribute to ground-breaking research aimed at elucidating the complexities of CRISPR/Cas9 technology and developing strategies to mitigate associated risks.
**We offer**:
**Start**: As soon as possible
Dr. Andrea Rossi
IUF - Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf
Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.
