(Senior) Research Associate

vor 23 Stunden

Planegg, Deutschland iOmx Therapeutics AG Vollzeit

**Your Tasks and Responsibilities**:
As a part of the Research Department, you will contribute to the discovery and characterization of novel immune-checkpoint targets and actively participate in the evolution of our proprietary screening and validation platform. You will work in a modern, semi-automated laboratory, and will be eager to continually evaluate and employ new state-of-the-art techniques for advancing our target-tailored drug screening efforts. Some of your daily tasks will involve:

- Validation of gene function in modulating immune cell (lymphoid and myeloid) responses using state-of-the-art methodologies (CRISPR, RNAi etc.)
- In vitro primary immune cell-based assays such as co-culture assays, immune cell activation and cytotoxicity assays
- Improvement and implementation of our proprietary high-throughput genetic screening platform
- Execution of immunological endpoint assays such as flow cytometry, ELISA, multiplex analysis and image analysis using IncuCyte live cell imaging device
- Target pathway analysis including overexpression, phosphoprotein analysis, transcriptomic sequencing
- Participate routinely in laboratory management and organization.
- Execution of experiments both independently and in a team, including diligent analysis, documentation, and presentation of your results in internal team meetings

**What we are looking for**:

- You hold a university degree (Bachelor’s or Master’s) in biology, molecular medicine, biotechnology, or a related field, or have completed a vocational training as laboratory assistant such as BTA, MTA, CTA and have at least 3 years of relevant work experience, preferably in an industry setting
- You have demonstrable experience with CRISPR/Cas-based genome editing methodology or in transfection/transduction of primary human immune cells or cell lines
- You possess hands-on experience in conducting immune cell-based functional assays (cytotoxicity assays, cytokine release assays, ELISA, bead-based multiplex assays, macrophage polarization assays etc.)
- You are familiar with standard cellular and molecular biology methods such as cloning, transduction/transfection of expression vectors in desired cell types, mutant generation, western blot, RNA sequencing preparation, phoshpo-flow or -plex analysis
- You are experienced in using data analysis software such as GraphPad Prism and Flow Jo
- You are motivated to work independently and collaboratively in a fast-paced biotech environment to meet project goals
- You are fluent in English (spoken and written)

**Why to join iOmx?**:
We are a young biotechnology company with about 50 employees in Martinsried/Munich. We are working in flat hierarchies with short decision-making processes and offer a rewarding career in a welcoming, trusting and international work environment.
By joining us you can expect the following:

- Opportunity for personal development
- Growth-oriented and innovation-driven company culture
- 30 days paid vacation
- Flexible working time and much more

**About us**:

- i_
- Omx Therapeutics is a clinical-stage company in the field of immuno-oncology located in Martinsried/Munich, Germany._
- We are focusing on the development of first-in-class cancer immunotherapies, addressing novel immune evasion biologies, which are hijacked by tumors and their microenvironment._
- We are looking for highly motivated, self-driven and competent colleagues who share our vision and wish to contribute to translating this vision into reality._

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