Post-doctoral scientist

Vor 3 Tagen

Heidelberg, Deutschland Universitätsklinikum Heidelberg Vollzeit

Our research focuses on iron metabolism and its disturbances in human disease. The major aim of the advertised project is to understand the role of iron in innate immune cells in the tumor microenvironment. We have recently shown that the instillation of iron nanoparticles into the lung delays tumor growth. Project-related publications: Horvat NK, Chocarro S, Marques O, Bauer TA, Qiu R, Diaz-Jimenez A, Helm B, Chen Y, Sawall S, Sparla R, Su L, Klingmüller U, Barz M, Hentze MW, Sotillo R, Muckenthaler MU Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment. ACS Nano. 2024 Apr 30;18(17):11025-11041. doi: Epub 2024 Apr 16. PMID: 38626916 Bauer TA, Horvat NK, Marques O, Chocarro S, Mertens C, Colucci S, Schmitt S, Carrella LM, Morsbach S, Koynov K, Fenaroli F, Blümler P, Jung M, Sotillo R, Hentze MW, Muckenthaler MU, Barz M. Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages. Adv Healthc Mater. 2021 Oct;10(19):e2100385. doi: Epub 2021 Jun 16. Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU. Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages Frontiers in Immunology, 8. 2017. Galy B, Conrad M, Muckenthaler M. Mechanisms controlling cellular and systemic iron homeostasis. Nat Rev Mol Cell Biol. 2023 Oct 2. doi: A suitable candidate will have a proven track record of research accomplishments including first author publications in international peer-reviewed journals. To successfully engage in this study experience with murine disease models (including FELASA licence) is an absolute requirement.  We require excellent experience in: molecular and cell biology techniques work with murine tumor models cell culture fluorescent microscopy ability to work independently and collaboratively with colleagues from different disciplines fluent written and spoken English  Goal-oriented, individual training and development opportunities ( state of the art technologies) Working with the latest techniques / technical equipment single cell sequencing, spatial transcriptomics  Possibility to publish scientifically is offered and supported Partial) project management / project responsibility possible if suitable  Regular team meetings Interdisciplinary cooperation with EMBL  Collectively agreed remuneration (TV-L E13), attractive company pension scheme (VBL) 30 days vacation Sustainable travel: job ticket Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care Wide range of health, prevention and sports offers

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