PhD Researcher in Pediatric Leukemia

vor 1 Woche

Frankfurt am Main, Hessen, Deutschland Universitätsklinikum Frankfurt Vollzeit
Research Opportunity in Pediatric Leukemia

We are seeking a highly motivated PhD student to join our Leukemia Research Group at the Department of Pediatrics and the Department of Experimental Pediatric Hematology & Oncology. Our joint labs are at the forefront of pediatric leukemia research, focusing on genetic and epigenetic analyses and pioneering innovative molecularly-guided therapeutic approaches.

Project Overview

The project aims to characterize the leukemia-initiating population in pediatric AML with flow cytometry-based enrichment combined with cutting-edge single-cell transcriptomics and proteomics as a basis for the development of targeted CAR-T-cell immunotherapies. The project will characterize persistent AML clones during treatment and remission, which can give rise to lethal relapse, identify their cell surface profile, and design and test CAR constructs towards the development of preclinical immunotherapy testing.

Requirements
  • Master's degree in life sciences or equivalent
  • Passion for discovery of novel therapy approaches and epigenetic mechanisms of gene regulation
  • Collaborative spirit & good communication skills
  • Experience in basic laboratory techniques (i.e. molecular biology, flow cytometry etc.)
  • Proficiency in spoken and written English
  • Due to legal regulations, valid proof of measles immunity / measles vaccination is required
What We Offer
  • Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes
  • Collaborative spirit: Experience in basic laboratory techniques (i.e. molecular biology, flow cytometry etc.), Proficiency in spoken and written English, Excellent scientific environment & dedicated mentoring, Training in novel cutting-edge techniques to study epigenetic mechanisms in leukemia cells, Collaboration opportunities with national & international world-leading laboratories, Participation in training and qualification programs of the MSNZ and the Goethe University
  • Mobility: Free public transport in all Hessen (Free State Ticket Hessen)
  • Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks
  • Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice), child care during holidays
  • Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise.
  • Professional development: Internal and external training for your professional development

Women are underrepresented in these positions at the University Hospital Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications.

Please submit your online application including a possible starting date and your salary expectations. For further information regarding the position and project, please contact: c.hugenberg@kinderkrebsstiftung-frankfurt.de or Sandra Kunz via mail: sandra.kunz@ukffm.de

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