Postdoctoral Researcher in Pediatric Leukemia Research

vor 2 Wochen

Frankfurt am Main, Hessen, Deutschland Universitätsklinikum Frankfurt Vollzeit
Postdoctoral Researcher in Pediatric Leukemia Research

We are seeking a highly motivated postdoctoral researcher to join our Leukemia Research Group at the Department of Pediatrics and the Department of Experimental Pediatric Hematology & Oncology. Our joint labs are at the forefront of pediatric leukemia research, focusing on genetic and epigenetic analyses and pioneering innovative molecularly-guided therapeutic approaches.

Project Overview

The project aims to establish novel therapeutic options in pediatric acute myeloid leukemia (AML) based on Europe's largest patient-derived xenograft (PDX) biobank for pediatric AML. You will utilize drug, shRNA, CRISPR-Cas9 and Cas13 libraries, and state-of-the-art cellular immunotherapeutics to discover and establish potent drug targets, drug combinations and cellular immunotherapy that efficiently target AML in vitro and in vivo using these PDX models.

Responsibilities
  • Maintain and expand the PDX biobank
  • Apply gene expression and single-nucleotide variants (SNV)-based characterization
  • Perform in silico prediction of druggable targets based on these data sources, followed by high-throughput drug testing
  • Supervise and collaborate with a research technician to ensure smooth laboratory operations
Requirements
  • PhD and publication record in life sciences or related field
  • Expertise in cell culture, flow cytometry, and molecular biology
  • Experience with mouse handling and animal experiments (FELASA certification required)
  • Ability to supervise and collaborate with a technician
  • Proficiency in spoken and written English
What We Offer
  • Collective agreement with an attractive salary and annual special payment
  • Long-term security through company pension schemes
  • Collaborative spirit with excellent scientific environment and dedicated mentoring
  • Training in novel cutting-edge techniques to study epigenetic mechanisms in leukemia cells
  • Collaboration opportunities with national & international world-leading laboratories

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