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Researcher in Neuroscience and Vascular Biology

vor 3 Monaten


Munich, Bayern, Deutschland LMU Klinikum Vollzeit

Overview of the Research Initiative

The blood-brain barrier (BBB) plays a crucial role in maintaining brain stability, yet it can also impede the delivery of therapeutic agents to areas affected by neurological disorders. This project aims to investigate and manipulate the cellular mechanisms that establish blood-brain barrier functionality in brain tumors, specifically gliomas. This could enhance the delivery of therapeutic agents into these tumors. We have created several transgenic mouse models that elucidate the cellular makeup, signaling pathways, and functionality of the BBB in both healthy and diseased states. Our in vivo models for BBB lineage tracing, lineage ablation, and our established single-cell RNA sequencing datasets provide a robust foundation for this research initiative. Our recent publications in prestigious journals highlight our commitment and capability for significant contributions to the fields of neuroscience and vascular biology.

Responsibilities

We seek an individual eager to intellectually contribute to the project, utilizing transgenic mouse models for neuroscience, examining brain physiology/pathology through advanced microscopy techniques, flow cytometry, and transcriptomics, and developing strategies for pharmacological intervention of the blood-brain barrier.

Qualifications

A relevant degree in biology or biochemistry is required. Experience in vascular research or neuroscience is advantageous. Strong teamwork skills, the ability to work independently, and excellent English communication skills are essential. Application Process: Candidates should submit a comprehensive curriculum vitae, academic certificates and transcripts, a motivation letter outlining their research interests, and contact details for two references. Applications must be compiled into a single PDF document.

Benefits

The PhD position is under the guidance of a distinguished professor in Neurosurgical Research at a leading university hospital. The project is fully funded for a duration of three years, with remuneration aligned with public sector standards. Compensation is based on the collective agreement for the public sector, including all standard allowances.