Biomedical Scientist

vor 3 Wochen

Heidelberg, Deutschland Deutsches Krebsforschungszentrum Vollzeit

**Position**:Biomedical Scientist / Molecular Biologist for Skin Cancer Research in full
- or part-time**

**Department**: Junior Research Group "Digital Biomarkers for Oncology"

**Code number**:2023-0258

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

The Junior Research Group "Digital Biomarkers for Oncology" (headed by Dr. Titus Brinker) is seeking a biomedical scientist or molecular biologist to work on a skin cancer research project.

Skin cancer is one of the most common cancers in Europe, and malignant melanoma in particular causes the highest number of skin cancer-attributable deaths. Melanomas are spatially heterogeneous, resulting in part from plastic changes in melanoma cells. It is not well understood how molecular plasticity and associated heterogeneity translate into specific histological structures of melanomas, and how this plasticity affects the prognosis of patients. In this interdisciplinary project, you will work together with an experienced data scientist from our team in Heidelberg and be responsible for the biomedical / biology part. The team will be supported by a dermatologist.

**Job description**:
The team will characterize plasticity-induced spatial heterogeneity at both the gene expression and histological levels and investigate the relationship between the different levels of heterogeneity and with patient prognosis. To this end, you will first develop methods to automatically annotate the different segments on histological sections of primary superficial spreading melanomas and investigate correlations. You will then define areas of maximal overlap between the segments defined by the different methods and use these to train an algorithm that identifies these areas on new melanoma sections. Hereby, you will investigate whether and, if so, how an analysis of the number and possibly area and/or distribution of these areas allows prognostic statements in the sense of a digital biomarker.

At the gene expression level, you will investigate transcriptional heterogeneity/plasticity using RNAscope in situ hybridization. Here, you determine the expression of selected genes from mesenchymal and melanocytic signatures previously described in melanoma cells. At the histological level, you will characterize the segments using two methods: by pathological annotation of different cell types and their subsequent automatic recognition using established pathology software (supervised learning) and by AI-based clustering without predefined classes (unsupervised learning). You will analyze the area variation of the segments defined by the different methods and perform correlation analyses between molecular and histological properties of these segments. Based on this, you will generate areas/segments on the sections that have the highest possible correlation between molecular and histological properties. With these "fusion segments", you will train a Deep Learning
- based segmentation algorithm to automatically annotate the plasticity-induced spatial heterogeneity also on new, unknown H&E-stained melanoma tissue sections and relate the thus defined heterogeneity to prognosis. If, as in other cancers, a correlation between extent of heterogeneity and prognosis is evident, you will attempt to use the segmentation algorithm results to train a risk classifier that can be used as a digital prognostic biomarker to predict recurrence or mortality risk.

**Requirements**:

- Preferably a bachelor's or master's degree in the field of life science
- Deep motivation to improve outcomes for cancer patients
- Background in biomedical research / molecular biology or related fields
- Strong interest in life sciences / working in interdisciplinary teams
- Self-dependent work ethic
- English language skills are required

**We offer**:

- Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
- Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
- 30 days of vacation per year
- Flexible working hours
- Possibility of mobile work and part-time work
- Family-friendly working environment, e.g. parent-child room, advisory services caring for elderly relatives
- Sustainable travel to work: subsidized Germany job ticket
- Unleash your full potential: targeted offers for your personal development to further develop your talents
- Our Corporate Health Management Program offers a holistic approach to your well-being

**Important notice**:
**Earliest Possible Start Date**: as soon as possible

**Duration**: The position is limited to 2 years.

**Application Deadline**:12.08.2023

**Contact**:
Dr. Titus Brinker
Phone 0151/75084347

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified f

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