PhD student
vor 1 Monat
We are seeking an enthusiastic and motivated PhD student to conduct research at the interface of neuroscience and immunology.
The student will be a member of the ‘Translational Neuroimmunology’ research group, led by Dr. Róisín McManus, which is based at the DZNE in Bonn and is also associated with the Institute of Innate Immunity at the University Hospital Bonn and the ImmunoSensation2 Cluster of Excellence.
Our research focuses on understanding how microglia-mediated neuroinflammation contributes to the progression of Alzheimer’s disease. Specifically, we examine how immune signaling and metabolic changes combine to modulate microglial function, affecting disease outcome.
Our recent work has uncovered that consumption of a western diet can drive lipid changes that activate microglia, causing neuroinflammation. Using a series of animal models of dementia, murine cell culture models and samples from patients, the goal of your PhD will be to unravel the innate immune pathways mediating these neuroinflammatory changes, and thus contribute to Alzheimer’s disease.
Specifically, this position will involve cell culture work using murine and human cells, immune activation assays and state of the art lab techniques (metabolic assays, flow cytometry, fluorescence imaging, RNA sequencing and biochemical techniques e.g. western blot, quantification assays). Combining diet treatments, pharmacological inhibition and genetic depletion approaches, the successful applicant will assess the full impact of western diet on microglial activity both in vivo, ex vivo and in vitro.
A MSc degree in one of the following fields: Immunology, Neuroscience, Biology or similarPrevious experience in experimental animal work and immunology, neuroscience or cell metabolism research would be very beneficialFELASA accreditation is a strong plusHands on experience in cell culture (e.g. murine microglia or microglia generated from human iPSCs) and biochemistry techniques (protein assays, western blot, PCR). Familiarity in immunohistochemistry or flow cytometry is a plusFluency in English for communicating, writing, and presentation of scientific dataEnthusiasm for exploring and innovating with new techniquesWillingness to work in a diverse and interdisciplinary team of international scientists
What our employees value
Innovation and internationality - a forward-looking infrastructure, modern laboratory and office equipment, software tools and the opportunity for international exchange with your colleagues from 65 nationsWork-life balance - we reconcile work and private life with flexible working hours, mobile working, 30 days' holiday (On top free on Christmas Eve and New Year's Eve) and subsidised job/ Germany ticket optionsFamily-conscious corporate culture - because we know that family is important, we support you with parent-child offices, family services and daycare co-operationsHealth promotion – through our extensive range of company health programmes, in cooperation with Sozialwerk.BundFocus on development - training programmes tailored to your individual needs and annual HR-development meetings for concrete prospects and potential developmentRemuneration and conditions according to TVöD-Bund - including annual special payment, capital-forming benefits and VBL supplementary pension schemePersonalised Onboarding - for a good start to your new professional challengeA feel-good working environment - our Bonn employees enjoy a campus surrounded by greenery, with on-site parking and public transport connections as well our company restaurantWeekly seminars -on immunology, neuroscience and other biomedical topics by national and international speakersPossibility to present results at national and international conferencesA position, which is initially limited to two yearsOnly applications submitted via our portals will be accepted. Please refrain from sending your application by e-mail.
We look forward to receiving your application via the link below.
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