Postdoctoral position in Bioinformatics/Computational Biology

Vor 2 Tagen


Bonn, Deutschland Universitätsklinikum Bonn Vollzeit

Das UKB verbindet als eines der leistungsstärksten Universitätsklinika Deutschlands Höchstleistungen in Medizin und Forschung mit exzellenter Lehre. Jährlich werden am UKB über eine halbe Million Patienten ambulant und stationär versorgt. Hier studieren rund 3.500 Menschen Medizin und Zahnmedizin, zudem werden jährlich über 600 Personen in Gesundheitsberufen ausgebildet. Mit rund 9.900 Beschäftigten ist das UKB der drittgrößte Arbeitgeber in der Region Bonn/Rhein-Sieg. In der Focus-Klinikliste belegt das UKB Platz 1 unter den Universitätsklinika in NRW und weist unter den Universitätsklinika bundesweit den zweithöchsten Case-Mix-Index (Fallschweregrad) auf. 2024 konnte das UKB knapp 100 Mio. € an Drittmitteln für Forschung, Entwicklung und Lehre einwerben. Das F.A.Z.-Institut zeichnete das UKB im vierten Jahr in Folge als "Deutschlands Ausbildungs-Champion" und "Deutschlands begehrtesten Arbeitgeber" aus.Wissenschaft und ForschungVollzeitPostdoctoral position in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 % ~ 38,5 h/week) Clinic of Pediatric Immunology and RheumatologyST-32021The group of Prof. Dr. med. Kaan Boztug at the Clinic of Pediatric Immunology and Rheumatology (Centre of Pediatric, University Hospital Bonn) offers aPostdoctoral position in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 % ~ 38,5 h/week)The position is offered as a fixed-term appointment until 30 September 2032, corresponding to the duration of the professorship.Join a Leading Research Program in Childhood Immune DysregulationThe newly established Clinic for Pediatric Immunology and Rheumatology at the University Hospital of Bonn, led by the Director, Prof. Kaan Boztug, is seeking a highly motivated and talented Postdoctoral Fellow in Bioinformatics/Computational Biology to join an interdisciplinary team investigating the genetic and molecular mechanisms of inborn errors of immunity (IEI), autoimmunity, and autoinflammation.Our research program integrates fundamental discoveries in immune dysregulation with translational medicine, aiming to uncover novel disease mechanism and develop targeted therapeutic approaches. Recent high-impact publications have uncovered monogenic causes of immune-mediated diseases, including Wang L et al., Nature Genetics 2021; Salzer E et al., Sci Immunol 2020; Block J et al., NEJM 2023; or Ransmayr B et al. Sci Immunol 2024.Our group also employs cutting-edge computational and systems biology approaches to support the diagnosis of IEIs and better understand cancer syndromes. These integrative analyses are central to translating genomic data into clinical insights (e.g., Haimel et al., J. Allergy Clin. Immunol. 2021; Guthrie J et al., Sci Adv 2023, Haladik et al., Cell Reports Medicine 2025).The position will focus on the computational analysis of multi-omics datasets (genomics, transctiptomics, proteomics, metabolomics and single-cell and spatial omics) to uncover disease pathways and therapeutic targets in pediatric patients. The candidate will work in close collaboration with wet-lab scientists and clinicians, contributing to the functional interpretation of genetic variants and the modelling of immunopathological pathways. The position will be closely integrated with other computational biologists at the ImmunoSensation2 Cluster of Excellence and other research groups.The project will integrates:Analyis of multi-omics data (WES/WGS, scRNA-seq, -omics)Variant interpretation and priorization in monogenic immune disordersPathway modeling and network-based approachesSystems immunology integration of molecular and clinical dataCollaborative projects involving patient-derived samples and model organismsWhat we offer:A dynamic, international and interdisciplinary working environment with a strong focus on immunologyClose collaboration with leading scientists in the field of pediatric immunology and rare immune disordersOpportunities for professional development and career advancement within the research communityIntegration into the Excellence Cluster of ImmunoSensation2 with an interdisciplinary network of excellent scientistsExcellent core facilities to support your research across the campusSalary according to the German salary scale TV-L EG13 (100% including additional benefits)Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leaveProvision for later: company pension schemeClever to work: Possibility of an interest-free loan to buy an e-bikeTailor-made education: Subsidized further education and trainingSystematic start: Structured inductionHealthy at work: Numerous health promotion offers, free membership in UKBfitEmployer benefits: preferential offers for employees (corporate benefits)Requirements:A PhD in Bioinformatics, Computational Biology, Systems Biology, or a related disciplineProven experience in multi-omics data analysis, variant interpretation, and/or statistical genomicsExtensive knowledge and practical experience of NGSExperience in the usage of R (including package development) and command line-based analysis tools (e.g. Python)Knowledge with public sequence databases, error correction algorithmsScientific experience in immunology, molecular and cell biology would be a plusStrong English skills with excellent writing and presentation abilitiesEnthusiastic and collaborative work attitudeWe are committed to diversity and equal opportunities. Our goal is to increase the proportion of women in areas where women are underrepresented and to particularly promote their careers. We therefore urge relevantly qualified women to apply. Applications are treated in accordance with the State Equal Opportunities Act. Applications from suitable people with proven severe disabilities and those of equal status are particularly welcome.Wir bietenZUKUNFTSSICHERER ARBEITGEBERZUKUNFTSSICHERER ARBEITGEBERAm UKB arbeiten Sie an einem Krankenhaus der Zukunft. Mit einer Jahresbilanz von 1,6 Mrd. im Jahre 2023, einem Jahresüberschuss von über 21 Millionen Euro und dem dritthöchsten Case Mix Index in Deutschland ist das UKB glänzend für die Zukunft aufgestelltBEZAHLUNG NACH TV-LBEZAHLUNG NACH TV-LTarifliche und leistungsgerechte Vergütung nach TV-L / TV-Ä an Universitätskliniken (inkl. Zusatzleistungen wie Jahressonderzahlungen)PRÄMIEN & SONDERZAHLUNGENPRÄMIEN & SONDERZAHLUNGENNach TV-L wird eine Jahressonderzahlung ausgezahlt und es gibt weitere Zusatzentlohungen wie unter anderem das Prämiensystem für die Übernahme von Zusatzaufgaben im Team, für ausgewählte Zusatzqualifikationen, Fachweiterbildungen und bei Festanstellung im Pflege-Pool. Außerdem gibt es die Einspringprämie für kurzfristige Einsätze innerhalb < 96 Stunden aus dem Dienst-FreiVORTEILE DES TV-EVORTEILE DES TV-EZusätzliche Leistung zur Entlastung in den TV-E berechtigten Bereichen (Entlastungstage)FLEXIBLE ARBEITSZEITENFLEXIBLE ARBEITSZEITENIndividuelle Arbeitszeitmodelle, Gleitzeit (bei Bürojobs), Home OfficeSTART MIT SYSTEMSTART MIT SYSTEMStrukturiertes Onboarding, fachspezifische und strukturierte Einarbeitung in einem fachkundigen Team, viele Praxisanleiter*innenBETRIEBLICHE ALTERSVORSORGEBETRIEBLICHE ALTERSVORSORGEBetriebliche Altersvorsorge bei der VBL sowie die Möglichkeit der Entgeltumwandlung bei der KlinikrenteATTRAKTIVSTE AUSBILDUNGSSTÄTTEATTRAKTIVSTE AUSBILDUNGSSTÄTTEAttraktives Ausbildungsgehalt, planbare 38,5 Stunden-Woche, 30 Tage Tarifurlaub mit zusätzlich 2 Zusatzurlaubstagen (TV-E), sehr gute Übernahmechancen nach der Ausbildung, ein Ausbildungsplatz in einem kollegialen Team mit strukturierter EinarbeitungWir setzen uns für Diversität und Chancengleichheit ein.Unser Ziel ist es, den Anteil von Frauen in Bereichen, in denen Frauen unterrepräsentiert sind, zu erhöhen und deren Karrieren besonders zu fördern. Wir fordern deshalb einschlägig qualifizierte Frauen nachdrücklich zur Bewerbung auf. Bewerbungen werden in Übereinstimmung mit dem Landesgleichstellungsgesetz behandelt. Die Bewerbung geeigneter Menschen mit nachgewiesener Schwerbehinderung und diesen gleichgestellten Personen ist besonders willkommen.Applicants should send their application in a single pdf file (max. 5 MB) including a motivation letter, CV, scanned academic degrees, list of publications and the contact details of two references until 18th of November toProf. Dr. med. Kaan BoztugPädiatrische Immunologie und RheumatologieSchwerbehindertenbeauftragte/rUniversitätsklinikum BonnVenusberg-Campus 153127 Bonn



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