Postdoc (M/F/d) in Computational Biology/multi-omics

NEU

Vollzeit

Forschung und Lehre

The Synthetic and Systems Biology Group at the Faculty of Biology, University of Freiburg, is seeking to recruit a Postdoc (M/F/d) in Computational Biology/Multi-Omics
- Bewerbungsfrist: 30. September 2025
- Veröffentlichungsdatum: 16. September 2025
- Eintrittstermin: Zum nächstmöglichen Zeitpunkt.
- Arbeitsumfang: Fulltime position
- Kennziffer: 00004530

**Beschreibung**:
We are offering a postdoc position (TV-L, 100%), to be filled as soon as possible, in a project elucidating the mechanisms of decision-making in cellular models of mammalian development using rapid perturbation biology and ‘omics and single cell readouts funded by the Alexander von Humboldt Foundation. The project will deepen our understanding of functional cell states present in early mammalian development and will seek to explain how key lineage choices are made. For example, we are using genetic and pharmacologic perturbations of human embryonic stem cells in combination with bulk and single cell transcriptomic and epigenomic readouts, in cellulo and in silico transcription factor footprinting and other cutting edge techniques to delineate mechanisms of early cell fate decisions.

Within the Elsässer Group, you will be immersed in a dedicated training and research environment that strives to pursue bold and creative ideas through a culture of collegiality, trust, and openness, where diverse perspectives are valued and collaboration fuels innovation. Located at the modern Signalhaus, also home of the Centre for Integrative Biological Signalling Studies Excellence Cluster, the laboratories offer state-of-the-art equipment and instrumentation for cutting edge research and technology development.

We offer:

- Postdoc position with salary according to TV-L (E13, 100 %)
- An exciting research program with the possibility to participate in many ongoing projects generating different ‘omics datasets
- A world-class research environment with cutting-edge instrumentation and core facilities
- A stimulating community of Signaling and Epigenetics spanning the CIBSS Cluster of Excellence, the University Clinic and the Max Planck Institute for Epigenetics
- Further training opportunities in form of courses, workshops and participation in research conferences

**Your duties:

- To analyse, integrate various types of ‘omics datasets using existing or custom-made pipelines
- Generate reproducible analyses workflows following the FAIR principle, conduct statistical tests, visualize data
- To proactively communicate with wet and dry lab colleagues in order to jointly interpreting results, developing and testing new hypotheses
- To develop new data analysis and integration strategies, including exploration of new ML/AI approaches.
- To implement tools and frameworks for data explorations and sharing, such as shiny apps
- To acquire or deepen knowledge in mammalian developmental gene regulation, epigenetics and signal transduction.
- To participate in data management and IT maintenance activities
- To diligently document, present and discuss your results at scientific conferences and as peer-reviewed publications

Your profile:

- Demonstrated knowledge and practical experience in proteomics / mass spectrometry or (epi)genomics data analysis
- Proficiency in Unix, R, Python and/or additional programming languages
- Knowledge of ML/AI-based methods are advantageous
- High proficiency in English (written and oral)
- Motivation, self-organization and team player skills

**Interested? Please direct inquiries about the position to**

The position is limited to 2 years. The salary will be determined in accordance with E13 TV-L.

**Bewerbung**:
Universität Freiburg Biologie II/Biochemie/Synthetische Biologie Prof. Dr. Simon Elsäßer Schänzlestr. 1 79104 Freiburg