Scientist, Chemistry

Vor 7 Tagen

Berlin, Deutschland Silence Therapeutics GmbH Vollzeit

Our 20-plus years of RNAi experience together with our validated mRNAi GOLD platform make us a partner of choice for pharmaceutical companies looking to access the benefits of the siRNA and add this revolutionary modality to their discovery pipeline. As pioneers in the design and development of siRNAs (short interfering RNAs), Silence Therapeutics is advancing a new generation of medicines to potentially address the needs of patients who have limited or inadequate treatment options.

Our mission is to use our technology to create a new generation of therapeutics that can improve patient outcomes and, in the process, build shareholder value.

We are developing a deep pipeline of innovative siRNAs based on our mRNAi GOLD platform for diseases with a genetic basis. The depth and versatility of our liver-targeting technology gives us the opportunity to address a wide range of conditions in virtually any therapeutic area. Our wholly-owned pipeline is currently focused in three therapeutic areas of high unmet need: hematology, cardiovascular, and rare diseases.

**Role Purpose**

We are seeking an Oligonucleotide Synthesis Chemist to join the Molecular Design Team at Silence Therapeutics, Berlin, Germany as soon as possible. This role is for a laboratory-based position in the Chemistry group, one out of four teams working on in house evolution of cell-specific siRNA. The contract is limited to a duration of 1 year. The successful applicant will be driving active research projects of the Molecular Design Team through synthesis of oligonucleotides and oligonucleotide conjugates as well as building blocks for oligonucleotide synthesis. The applicant will be reviewing the related scientific literature landscape and report research results to interdisciplinary teams.

**Key Responsibilities**
- Perform oligonucleotide synthesis according to standard methods
- Research and establish new synthesis and conjugation procedures
- Manage synthesis of building blocks used in oligonucleotide synthesis
- Write scientific protocols and reports
- Actively participate in discussion and communicate your results in multidisciplinary teams
- Work in close collaboration with highly qualified chemistry technicians

**Skills/Competencies**
- Hands on experience with automated (oligonucleotide or peptide) synthesizer platforms is a must
- Broad knowledge of organic chemistry and especially oligonucleotide chemistry/synthesis
- Hands-on experience in the analysis of biomolecules would be an advantage
- A high level of creativity and independence in developing synthesis methods and solving complex problems
- Excellent command of written and spoken English, good working knowledge of German would be a plus
- Passionate about collaborative working and building relationships to reach joint goals
- Has a desire to broaden their experience, expand existing skills and knowledge, and add value to our growing organisation
- Clear affiliation with our vision and values, and a true ambassador of our organisation

Art der Stelle: Vollzeit, Befristeter Vertrag
Vertragsdauer: 12 Monate

Arbeitszeiten:

- Montag bis Freitag
- Tagschicht

Leistungen:

- Betriebliche Altersvorsorge
- Firmenhandy
- Flexible Arbeitszeiten

Ausbildung:

- Promotion/Doktorat (Wünschenswert)

Sprache:

- Deutsch (Wünschenswert)
- Englisch (Erforderlich)

Arbeitsort: Vor Ort

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