Phd Student Position in Bioengineering

vor 2 Wochen

Heidelberg, Deutschland Universität Heidelberg Vollzeit

At the Center for Organismal Studies (COS) the following position is to be filled with 25,675 h/week:
**PhD Student Position in Bioengineering (f/m/d)**

Project: Correlative super-resolution light and X-ray microscopy to probe genome organisation

Chromatin organization plays an important role in the regulation and maintenance of genes in the normal biological process and in response to environment. The disruption of the organization of chromatin has a significant impact on many cell processes, often associated with many pathological processes such as aging and cancer. Recent advances in microscopy techniques open up new opportunities to directly visualize higher-order chromatin architecture, its compaction status and its functional states at nanometer resolution in the intact cells or tissue.

The project aims to develop correlative imaging based on super resolution fluorescence and soft x-ray microscopies in 3D via full-field rotation. Such full-field rotation will enable structural and functional studies to probe chromatin architecture in key cellular processes at nanometer resolution in 3D. Full-rotation, tomographic imaging is the unique way to obtain 3D cell structure with isotropic resolution. While means for full-rotation soft x-ray tomography are established, super-resolution techniques are typically limited to 2D information or confocal geometry. This project focuses on development of axial super-resolution microscopy which is compatible with thin glass-wall capillaries used in soft x-ray tomography. The project is part of the doctoral networks within Marie Skłodowska-Curie Actions with the reach portfolio in correlated microscopy across light, electrons and x-rays. The joint effort of 9 collaborating institutions (clexm.eu/) and possibility to exchange expertise and gain new experiences.

**Your tasks**:
Full-rotation, tomographic imaging is the unique way to obtain 3D cell structure with isotropic resolution. While means for full-rotation soft x-ray tomography are established, super-resolution techniques are typically limited to 2D information or confocal geometry. This project focuses on development of axial super-resolution microscopy which is compatible with thin glass-wall capillaries used in soft x-ray tomography.
- Development of axial super-resolution microscopy on thin glass-wall capillaries, including sample preparation, image acquisition and plunge freezing
- Development of fiducial markers and volume analysis pipelines to correlate soft x-ray tomography and super-resolution microscopy
- 3D mapping of chromatin compaction by means of correlative approach to understand formation of memory in immune cells

**Your profile**:

- M.S. in Physics, Engineering, Biophysics, Cell or Molecular Biology or related disciplines
- interest in imaging techniques, joy in solving technical puzzles
- experience in handling microscopes
- experience in data analysis or programming using MATLAB/Python/R
- good English language skills

Remuneration is based on TV-L (up to E 13, depending on qualifications). The position is limited for 3 years.

  • Phd Student Position in Epidemiology

    vor 2 Wochen

    Heidelberg, Deutschland Deutsches Krebsforschungszentrum Vollzeit

    **Reference number**:2024-0349** - Heidelberg- Full-time- Cancer Epidemiology*** **_“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely...

  • PhD position “Centriole Duplication”

    vor 3 Minuten

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    PhD position “Centriole Duplication” (f/m/d)60 % Are you passionate about cell biology and eager to explore the fascinating world of centrioles? Prof. Elmar Schiebel at the Centre for Molecular Biology (ZMBH) at Heidelberg University invites applications for a PhD position focusing on centriole biogenesis. About the Position: The successful candidate...

  • Phd Position in Biology

    vor 2 Wochen

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    Heidelberg University is a comprehensive university with a strong focus on research and an international standards. With around 30,000 students and 8,400 employees, including numerous top researchers, it is a globally respected institution that also has outstanding economic significance for the Rhine-Neckar metropolitan region. The Center for Organismal...

  • Phd Position in Biology

    vor 2 Wochen

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    Heidelberg University is a comprehensive university with a strong focus on research and an international standard. With around 30,000 students and 8,400 employees, including numerous top researchers, it is a globally respected institution that also has outstanding economic significance for the Rhine-Neckar metropolitan region. The Center for Organismal...

  • Phd and Postdoc Positions

    vor 2 Wochen

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    **Heidelberg University** is a comprehensive university with a strong focus on research and international standards. With around 30,000 students and 8,400 employees, including numerous top researchers, it is a globally recognised institution that is also of outstanding economic importance for the Rhine-Neckar metropolitan region. The University has recently...

  • Phd Position in Development Economics

    vor 2 Wochen

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    The Chair of Development Economics (Prof. Stefan Klonner) at Heidelberg University’s South Asia Institute, Germany, seeks to fill a **PhD Position in Development Economics (66.6%) (f/m/d)** **Job description**: Development economics is a research-intensive focus within economics in Heidelberg. At the South Asia Institute’s Department of Development...

  • Phd Student in 4d Genome and Gene Regulation

    Vor 7 Tagen

    Heidelberg, Deutschland Deutsches Krebsforschungszentrum Vollzeit

    **Reference number**:2025-0249** - Heidelberg - Full-time - Mechanisms of Genome Control **_“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more...

  • Postdoctoral Position

    vor 2 Wochen

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    **Postdoctoral position: Microsensors for cells and organoids (f/m/d)** The position is funded by the Carl-Zeiss-Stiftung (CZS) **Background**: - Three-dimensional cell cultures are important to enable realistic cell environments for disease modeling and to analyze cell interactions. This position will address the question of how one can develop...

  • Phd Position

    vor 2 Wochen

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    The research group of Prof. Dr. Michael Mastalerz at the Institute of Organic Chemistry, Heidelberg University is seeking the following temporary position from October 15th 2025 or later: **PhD Position (65%) in Organic Chemistry (f/m/d)** Synthesis of Polycyclic Aromatic Nanobelts TACY (Tackling the Cyclacene Challenge) is a joint project between the...

  • Postdoc Position

    vor 2 Wochen

    Heidelberg, Deutschland Universität Heidelberg Vollzeit

    **Postdoc Position - Computer Architecture/VLSI (f/m/d)** Heidelberg University is a comprehensive university with a strong focus on research at the highest international standards. With around 30,000 students and 8,400 employees, including numerous top researchers, it is a globally respected institution continuously ranked among the top 3 German...