Postdoc Position in Pancreatic Cancer Immunology and Computational Biology

The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members. The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and exploration across many disciplines. We provide a dynamic environment which empowers excellence with state-of-the-art technologies, cutting edge infrastructure, and a global scientific network. Contribute your knowledge, vision, and dedication to create a space where scientific discovery in cancer research is transformed into benefits for human health. Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK). The Institute of Translational Cancer Research and Experimental Cancer Therapy (headed by Prof. Dr. Dieter Saur) at the DKTK partner site Munich is offering for the next possible date 2 Postdoc Positions in Pancreatic Cancer Immunology and Computational Biology Reference number: - * München * Full-time * DKTK partner site Munich - Institute of Translational Cancer Research and Experimental Cancer Therapy, TUM The Saur Lab is deploying advanced in vitro and in vivo model systems, genetic perturbations and single-cell technologies with spatial readouts to study the distinct routes of tumor evolution and modes of immunosuppression we identified in our previous work in subtypes of pancreatic cancer (e.g., Nat Commun. 14: and 14:; Nature Cancer 3:-, Cancer Discovery 11:-, Nature :62-68; Nat. Rev. Cancer 17:-; Nat. Commun. , 7:; Nat Med. , 20:-7). During the past decade, our lab has generated a comprehensive resource of pancreatic primary tumors and primary cell cultures. Multiple NGS methods and biological readouts have been conducted to decipher the molecular makeup and phenotypes of these tumors. The advertised projects focus on unraveling targetable nodes of the cancer-immune niche and its impact on treatment response and resistance, develop novel immunotherapies for pancreatic cancer subtypes, and developing computational single-cell and spatial transcriptomics pipelines to investigate tumor subtype specific genetic interactions in close collaboration with the Theis lab at Helmholtz Center Munich. We are an enthusiastic and international team and offer intensive training and mentoring. Your Tasks The successful candidates will have the opportunity to: * Gain important insights into clinically relevant aspects of cancer development and therapy * Perform state-of-the-art in vivo experiments and large-scale drug and genetic screens * Apply a wide spectrum of genetic, molecular, and cell biology, biochemical as well as immunological, and bioinformatics techniques to study translational aspects of cancer (e.g., Cre/loxP and Flp/FRT-based dual and triple recombinase systems, organoid culture, orthotopic transplantations of cells/organoids, CRISPR/Cas9, molecular in vivo imaging, quantitative proteomics/phosphoproteomics, multiple transcriptomics and genomics approaches, single-cell sequencing, and histocytometry) * Set up bioinformatics platforms and develop computational pipelines for the analysis of bulk and single-cell RNA sequencing, DNA sequencing datasets, and proteomics * Integrate these datasets with molecular (WES, WGBS, lcWGS, ChIPseq, ATACseq), phenotypic (e.g. histology), drug screening, and clinical information * Interact within a diverse and multidisciplinary environment of biologists, clinicians, computational scientists, and mathematicians within the TranslaTUM Your Profile We are looking for exceptional, self-motivated, bright individuals with a diploma or master’s degree in bioinformatics, biochemistry, biology, molecular/translational medicine or related subjects and a PhD in life and computer sciences. Previous exposure to and experience with basic biochemical and molecular biology techniques, proteomics, and bioinformatics, as well as interests in molecular aspects of cancer research, are essential. Due to the interdisciplinary framework and close collaboration between wet-lab and computational scientists, good communicative skills in English are essential. German language skills are not required. We Offer * Excellent framework conditions: state-of-the-art equipment and oppor­tunities for inter­national networking at the highest level * Remuneration according to TV-L incl. occupational pension plan and capital-forming payments * 30 days of vacation per year * Flexible working hours * Possibility of part-time work * Family-friendly working environ­ment * Sustainable travel to work: subsidized Germany job ticket * Our Corporate Health Manage­ment Program offers a holistic approach to your well-being * Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents Contact: Prof. Dr. Dieter Saur Phone: 89 - The positions are initially limited to 2 years. An extension is possible. Application Deadline: 05.12. Applications by e-mail cannot be accepted. Please also note that we cannot return applications submitted by post. Are you interested? Then become part of the DKFZ and join us in contributing to a life without cancer Apply now We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude. Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles. Share this job Deutsches Krebsforschungszentrum | Im Neuenheimer Feld | Heidelberg | Deutsches Krebsforschungszentrum (DKFZ) Website Website -12-04T23:00:00Z FULL_TIME EUR YEAR null -10-30 München Pettenkoferstraße 8A 48. 11.