2 Postdoc Positions in Pancreatic Cancer Immunology and Computational Biology

2 Postdoc Positions in Pancreatic Cancer Immunology and Computational Biology Reference number: 2025-0274 München Full-time DKTK partner site Munich - Institute of Translational Cancer Research and Experimental Cancer Therapy, TUM The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members. The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and exploration across many disciplines. We provide a dynamic environment which empowers excellence with state-of-the-art technologies, cutting edge infrastructure, and a global scientific network. Contribute your knowledge, vision, and dedication to create a space where scientific discovery in cancer research is transformed into benefits for human health. Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).The Institute of Translational Cancer Research and Experimental Cancer Therapy (headed by Prof. Dr. Dieter Saur) at the DKTK partner site Munich is offering for the next possible date The Saur Lab is deploying advanced in vitro and in vivo model systems, genetic perturbations and single-cell technologies with spatial readouts to study the distinct routes of tumor evolution and modes of immunosuppression we identified in our previous work in subtypes of pancreatic cancer (e.g., Nat Commun. 2023 14:2642 and 14:1201; Nature Cancer 2022 3:318-336, Cancer Discovery 2021 11:3158-3177, Nature 2018 554:62-68; Nat. Rev. Cancer 2017 17:239-253; Nat. Commun. 2016, 7:10770; Nat Med. 2014, 20:1340-7). During the past decade, our lab has generated a comprehensive resource of pancreatic primary tumors and primary cell cultures. Multiple NGS methods and biological readouts have been conducted to decipher the molecular makeup and phenotypes of these tumors. The advertised projects focus on (1) unraveling targetable nodes of the cancer-immune niche and its impact on treatment response and resistance, (2) develop novel immunotherapies for pancreatic cancer subtypes, and (3) developing computational single-cell and spatial transcriptomics pipelines to investigate tumor subtype specific genetic interactions in close collaboration with the Theis lab at Helmholtz Center Munich. We are an enthusiastic and international team and offer intensive training and mentoring. Your Tasks The successful candidates will have the opportunity to:Gain important insights into clinically relevant aspects of cancer development and therapyPerform state-of-the-art in vivo experiments and large-scale drug and genetic screensApply a wide spectrum of genetic, molecular, and cell biology, biochemical as well as immunological, and bioinformatics techniques to study translational aspects of cancer (e.g., Cre/loxP and Flp/FRT-based dual and triple recombinase systems, organoid culture, orthotopic transplantations of cells/organoids, CRISPR/Cas9, molecular in vivo imaging, quantitative proteomics/phosphoproteomics, multiple transcriptomics and genomics approaches, single-cell sequencing, and histocytometry)Set up bioinformatics platforms and develop computational pipelines for the analysis of bulk and single-cell RNA sequencing, DNA sequencing datasets, and proteomicsIntegrate these datasets with molecular (WES, WGBS, lcWGS, ChIPseq, ATACseq), phenotypic (e.g. histology), drug screening, and clinical informationInteract within a diverse and multidisciplinary environment of biologists, clinicians, computational scientists, and mathematicians within the TranslaTUM Your ProfileWe are looking for exceptional, self-motivated, bright individuals with a diploma or master’s degree in bioinformatics, biochemistry, biology, molecular/translational medicine or related subjects and a PhD in life and computer sciences. Previous exposure to and experience with basic biochemical and molecular biology techniques, proteomics, and bioinformatics as well as interests in molecular aspects of cancer research, are essential. Due to the interdisciplinary framework and close collaboration between wet-lab and computational scientists, good communicative skills in English are essential. German language skills are not required. We Offer Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level Remuneration according to TV-L incl. occupational pension plan and capital-forming payments 30 days of vacation per year Flexible working hours Possibility of part-time work Family-friendly working environment Sustainable travel to work: subsidized Germany job ticket Our Corporate Health Management Program offers a holistic approach to your well-being Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents