Senior Research Scientist for Lipid Nanoparticle Formulation

vor 2 Wochen

Mainz, Rheinland-Pfalz, Deutschland DKFZ Vollzeit
Lipid Nanoparticle Formulation Expert for Cell-Specific Biomolecule Delivery

At the German Cancer Research Center (DKFZ), we are seeking a skilled and motivated senior postdoc to lead the development and optimization of lipid nanoparticle formulation for cell-specific biomolecule delivery.

Your Tasks
  • Develop and optimize LNP formulation for cell-specific biomolecule delivery, including high-throughput screening of lipid compositions and formulation parameters
  • Develop and apply methods for LNP purification and characterization
  • Apply in vitro and in vivo models to assess biodistribution, efficiency, toxicity, and cell-specific LNP uptake
  • Lead the development of LNP targeting strategies using ligand conjugation, peptides, or antibodies for cell/tissue-specific delivery
  • Present research findings internally and externally and publish in peer-reviewed scientific journals
  • Identify new research directions, develop grant proposals, and contribute to securing external funding
Your Profile
  • Masters degree and PhD in pharmaceutical sciences, chemistry, bio- or chemical engineering, or related fields
  • Extensive experience in LNP formulation methods, including hands-on experience with microfluidic devices, and targeted delivery strategies, including bioconjugation techniques
  • Deep knowledge in nanoparticle purification and characterization
  • Strong background in relevant in vitro and in vivo models and approaches for evaluating key parameters of nanoparticles
  • Proven publication record in high-impact journals related to biological therapeutics and nanomedicine
  • Meticulous, quality-focused, and able to work independently while consistently meeting deadlines with a high degree of accuracy and efficiency
  • Strong written and oral communication skills in English with effective interpersonal skills that foster teamwork and collaboration
We Offer
  • Excellent framework conditions, including state-of-the-art equipment and opportunities for international networking
  • Remuneration according to TV-L, including occupational pension plan and capital-forming payments
  • 30 days of vacation per year
  • Flexible working hours
  • Possibility of part-time work
  • Ffamily-friendly working environment
  • Sustainable travel to work with subsidized Germany job ticket
  • Access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for personal development

The Helmholtz Institute HI-TRON is a collaboration between the German Cancer Research Center and the Research Institute for Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz. Our mission is to develop effective immunotherapies and identify novel biomarkers for assessing the effectiveness of treatment.

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