Research Scientist in Pediatric Leukemia and Immunotherapy
vor 2 Wochen
We are seeking a highly motivated postdoctoral researcher to join our Leukemia Research Group at the Department of Pediatrics and the Department of Experimental Pediatric Hematology & Oncology at the Universitätsklinikum Frankfurt.
Project OverviewThe project aims to establish novel therapeutic options in pediatric acute myeloid leukemia (AML) based on Europe's largest patient-derived xenograft (PDX) biobank for pediatric AML. The postdoctoral researcher will utilize drug, shRNA, CRISPR-Cas9, and Cas13 libraries as well as state-of-the-art cellular immunotherapeutics to discover and establish potent drug targets, drug combinations, and cellular immunotherapy that efficiently target AML in vitro and in vivo using these PDX models.
Responsibilities- Maintain and expand the PDX biobank
- Apply gene expression and single-nucleotide variants (SNV)-based characterization
- Perform in silico prediction of druggable targets based on these data sources, followed by high-throughput drug testing
- Supervise and collaborate with a research technician to ensure smooth laboratory operations
- Key techniques include the use of high-throughput platforms such as drug, shRNA, and CRISPR-Cas9/13 libraries, generation of cellular immunotherapeutics as well as cellular assays with primary murine and human cells
- Flow cytometry and gene expression analysis (RNA-Seq, Western blots) will be central to the project
- PhD and publication record in life sciences or a related field
- Expertise in cell culture, flow cytometry, and molecular biology
- Experience with mouse handling and animal experiments (FELASA certification required)
- Ability to supervise and collaborate with a technician
- Proficiency in spoken and written English
- A collaborative team player with excellent communication skills
- Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes
- Collaborative spirit: Excellent scientific environment and dedicated mentoring, training in novel cutting-edge techniques to study epigenetic mechanisms in leukemia cells, collaboration opportunities with national and international world-leading laboratories, participation in training and qualification programs of the MSNZ and the Goethe University
- Mobility: Free public transport in all Hesse (Free Hesse StateTicket)
- Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces
- Work-life balance: Part-time employment is possible. We offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice) and child care during holidays
- Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports, and exercise
- Professional development: Internal and external training for your professional development
Women are underrepresented in these positions at the Universitätsklinikum Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications.
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