Research Scientist in Pediatric Leukemia and Immunotherapy

vor 2 Wochen

Wiesbaden, Hessen, Deutschland Universitätsklinikum Frankfurt Vollzeit
Postdoctoral Researcher in Pediatric Leukemia Research

We are seeking a highly motivated postdoctoral researcher to join our Leukemia Research Group at the Department of Pediatrics and the Department of Experimental Pediatric Hematology & Oncology at the Universitätsklinikum Frankfurt.

Project Overview

The project aims to establish novel therapeutic options in pediatric acute myeloid leukemia (AML) based on Europe's largest patient-derived xenograft (PDX) biobank for pediatric AML. The postdoctoral researcher will utilize drug, shRNA, CRISPR-Cas9, and Cas13 libraries as well as state-of-the-art cellular immunotherapeutics to discover and establish potent drug targets, drug combinations, and cellular immunotherapy that efficiently target AML in vitro and in vivo using these PDX models.

Responsibilities
  • Maintain and expand the PDX biobank
  • Apply gene expression and single-nucleotide variants (SNV)-based characterization
  • Perform in silico prediction of druggable targets based on these data sources, followed by high-throughput drug testing
  • Supervise and collaborate with a research technician to ensure smooth laboratory operations
  • Key techniques include the use of high-throughput platforms such as drug, shRNA, and CRISPR-Cas9/13 libraries, generation of cellular immunotherapeutics as well as cellular assays with primary murine and human cells
  • Flow cytometry and gene expression analysis (RNA-Seq, Western blots) will be central to the project
Requirements
  • PhD and publication record in life sciences or a related field
  • Expertise in cell culture, flow cytometry, and molecular biology
  • Experience with mouse handling and animal experiments (FELASA certification required)
  • Ability to supervise and collaborate with a technician
  • Proficiency in spoken and written English
  • A collaborative team player with excellent communication skills
What We Offer
  • Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes
  • Collaborative spirit: Excellent scientific environment and dedicated mentoring, training in novel cutting-edge techniques to study epigenetic mechanisms in leukemia cells, collaboration opportunities with national and international world-leading laboratories, participation in training and qualification programs of the MSNZ and the Goethe University
  • Mobility: Free public transport in all Hesse (Free Hesse StateTicket)
  • Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces
  • Work-life balance: Part-time employment is possible. We offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice) and child care during holidays
  • Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports, and exercise
  • Professional development: Internal and external training for your professional development

Women are underrepresented in these positions at the Universitätsklinikum Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications.

  • Biologe (f/m/x) - Leukemia Research Scientist

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland Universitätsklinikum Frankfurt Vollzeit

    Postdoctoral Researcher in Pediatric LeukemiaWe are seeking a highly motivated postdoctoral researcher to join our Leukemia Research Group at the Department of Pediatrics and the Department of Experimental Pediatric Hematology & Oncology.The successful candidate will contribute to the discovery and establishment of novel therapeutic options in pediatric...

  • Biologe (f/m/x) - Leukemia Research Scientist

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland Universitätsklinikum Frankfurt Vollzeit

    Postdoctoral Researcher in Pediatric LeukemiaWe are seeking a highly motivated postdoctoral researcher to join our Leukemia Research Group at the Department of Pediatrics and the Department of Experimental Pediatric Hematology & Oncology.The successful candidate will contribute to the discovery and establishment of novel therapeutic options in pediatric...

  • Research Scientist

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland SCHOTT AG Vollzeit

    ## Your ContributionWe are seeking a highly skilled professional to join our team at SCHOTT AG. As a Research Fellow, you will play a key role in integrating materials simulation and materials informatics approaches with industrial processes.Your primary responsibility will be to analyze material-process-property relations to meet future product...

  • Research Scientist

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland SCHOTT AG Vollzeit

    ## Your ContributionWe are seeking a highly skilled professional to join our team at SCHOTT AG. As a Research Fellow, you will play a key role in integrating materials simulation and materials informatics approaches with industrial processes.Your primary responsibility will be to analyze material-process-property relations to meet future product...

  • Director of Corporate Research and Development

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland SCHOTT AG Vollzeit

    Job DescriptionTo strengthen our Management Team within the Corporate Research & Development department, we are seeking a highly skilled professional to manage the competence life cycle, taking into account unique, synergistic, and performing criteria. The ideal candidate will provide proactive impetus for new product and technology developments throughout...

  • Director of Corporate Research and Development

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland SCHOTT AG Vollzeit

    Job DescriptionTo strengthen our Management Team within the Corporate Research & Development department, we are seeking a highly skilled professional to manage the competence life cycle, taking into account unique, synergistic, and performing criteria. The ideal candidate will provide proactive impetus for new product and technology developments throughout...

  • AFM Applications Scientist

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland Oxford Instruments Plc Vollzeit

    About the RoleOxford Instruments Plc is seeking an experienced AFM Applications Scientist to join our team in Wiesbaden. As a key member of our sales and support team, you will be responsible for organizing and executing all applications and post-sale support in designated territories, providing technical service as required.Key ResponsibilitiesSupport the...

  • AFM Applications Scientist

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland Oxford Instruments Plc Vollzeit

    About the RoleOxford Instruments Plc is seeking an experienced AFM Applications Scientist to join our team in Wiesbaden. As a key member of our sales and support team, you will be responsible for organizing and executing all applications and post-sale support in designated territories, providing technical service as required.Key ResponsibilitiesSupport the...

  • AFM Applications Scientist

    vor 1 Woche

    Wiesbaden, Hessen, Deutschland Oxford Instruments Plc Vollzeit

    About the RoleOxford Instruments Plc is seeking an experienced AFM Applications Scientist to join our team in Wiesbaden. As a key member of our sales and support team, you will be responsible for organizing and executing all applications and post-sale support in designated territories, providing technical service as required.Key ResponsibilitiesSupport the...

  • AFM Applications Scientist

    vor 1 Woche

    Wiesbaden, Hessen, Deutschland Oxford Instruments Plc Vollzeit

    About the RoleOxford Instruments Plc is seeking an experienced AFM Applications Scientist to join our team in Wiesbaden. As a key member of our sales and support team, you will be responsible for organizing and executing all applications and post-sale support in designated territories, providing technical service as required.Key ResponsibilitiesSupport the...

  • Technical Service and Development Scientist for Wire

    vor 1 Monat

    Wiesbaden, Hessen, Deutschland DOW PRODUKTIONS UND VERTRIEBS & CO. OHG Vollzeit

    About the RoleWe are seeking a highly skilled Technical Service and Development Scientist to join our team in Wiesbaden, Germany. As a key member of our Technical Service and Development (TS&D) group, you will be responsible for developing and implementing products to meet the needs of our customers in the Wire & Cable market.Key ResponsibilitiesDevelop and...

  • Technical Service and Development Scientist for Wire

    vor 1 Monat

    Wiesbaden, Hessen, Deutschland DOW PRODUKTIONS UND VERTRIEBS & CO. OHG Vollzeit

    About the RoleWe are seeking a highly skilled Technical Service and Development Scientist to join our team in Wiesbaden, Germany. As a key member of our Technical Service and Development (TS&D) group, you will be responsible for developing and implementing products to meet the needs of our customers in the Wire & Cable market.Key ResponsibilitiesDevelop and...

  • Technical Service and Development Scientist for Wire

    vor 1 Monat

    Wiesbaden, Hessen, Deutschland DOW PRODUKTIONS UND VERTRIEBS & CO. OHG Vollzeit

    About the RoleWe are seeking a highly skilled Technical Service and Development Scientist to join our team in Wiesbaden, Germany. As a key member of our Technical Service and Development (TS&D) group, you will be responsible for developing and implementing products to meet the needs of our customers in the Wire & Cable market.Key ResponsibilitiesDevelop and...

  • Technical Service and Development Scientist for Wire

    vor 1 Monat

    Wiesbaden, Hessen, Deutschland DOW PRODUKTIONS UND VERTRIEBS & CO. OHG Vollzeit

    About the RoleWe are seeking a highly skilled Technical Service and Development Scientist to join our team in Wiesbaden, Germany. As a key member of our Technical Service and Development (TS&D) group, you will be responsible for developing and implementing products to meet the needs of our customers in the Wire & Cable market.Key ResponsibilitiesDevelop and...

  • Technical Service and Development Scientist for Wire

    vor 3 Wochen

    Wiesbaden, Hessen, Deutschland DOW PRODUKTIONS UND VERTRIEBS & CO. OHG Vollzeit

    About the RoleWe are seeking a highly skilled Technical Service and Development Scientist to join our team in Wiesbaden, Germany. As a key member of our Technical Service and Development group, you will be responsible for developing and implementing products to meet the needs of our customers in the Wire & Cable market.Key ResponsibilitiesDevelop and...

  • Technical Service and Development Scientist for Wire

    vor 3 Wochen

    Wiesbaden, Hessen, Deutschland DOW PRODUKTIONS UND VERTRIEBS & CO. OHG Vollzeit

    About the RoleWe are seeking a highly skilled Technical Service and Development Scientist to join our team in Wiesbaden, Germany. As a key member of our Technical Service and Development group, you will be responsible for developing and implementing products to meet the needs of our customers in the Wire & Cable market.Key ResponsibilitiesDevelop and...

  • Data Scientist, Mid

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland Booz Allen Hamilton Vollzeit

    About the RoleWe are seeking a highly skilled Data Scientist to join our team at Booz Allen Hamilton. As a Data Scientist, you will be responsible for collecting, analyzing, and interpreting complex data to inform business decisions. You will work closely with our clients to understand their needs and develop data-driven solutions to drive business...

  • Data Scientist, Mid

    vor 2 Wochen

    Wiesbaden, Hessen, Deutschland Booz Allen Hamilton Vollzeit

    About the RoleWe are seeking a highly skilled Data Scientist to join our team at Booz Allen Hamilton. As a Data Scientist, you will be responsible for collecting, analyzing, and interpreting complex data to inform business decisions. You will work closely with our clients to understand their needs and develop data-driven solutions to drive business...

  • Senior Neonatologist

    vor 1 Monat

    Wiesbaden, Hessen, Deutschland FRESENIUS_HELIOS_HOSPITALS Vollzeit

    This position involves:Participation in specialist on-call servicesMedical care for neonatal and pediatric patients in the PICU/NICU and neonatal Intermediate Care Station as well as general pediatric patientsAccompanying Baby-NAW missionsPotential involvement in international patient transport (ambulance flights)Regular participation in and contribution to...

  • Senior Neonatologist

    vor 2 Monaten

    Wiesbaden, Hessen, Deutschland FRESENIUS_HELIOS_HOSPITALS Vollzeit

    This position involves:Participation in specialist on-call servicesMedical care for neonatal and pediatric patients in the PICU/NICU and neonatal Intermediate Care Station as well as general pediatric patientsAccompanying Baby-NAW missionsPotential involvement in international patient transport (ambulance flights)Regular participation in and contribution to...