Student Assistant with Bachelor Degree

vor 2 Wochen


Heidelberg, Baden-Württemberg, Deutschland Universität Heidelberg Vollzeit
Master Thesis Project: Engineering the Human Gamma-TuRC in Yeast

Join our research team at the Center of Molecular Biology and Center of Organismic Studies, Heidelberg University, Germany

We are seeking a highly motivated and skilled Student Assistant with a Bachelor Degree to join our research team for a master thesis project. The project focuses on engineering the human gamma-TuRC in yeast, a complex microtubule organizer in human cells.

Project Overview

The gamma-TuRC is a 14-spoked helical structure composed of over 40 subunits. Our team has resolved its structure using cryo-electron microscopy, revealing the assembly mechanism. In this project, we will use budding yeast Saccharomyces cerevisiae as a model system to express all human gamma-TuRC subunits.

Key Responsibilities

  • Assemble a chromosome derived from synthetic DNA fragments of the gamma-TuRC genes in collaboration with the Zeiss Center of Synthetic Genomics
  • Analyze the assembly of the gamma-TuRC using fluorescence microscopy, biochemical approaches, single-particle cryo-electron microscopy, and cryo-electron tomography
  • Tether the gamma-TuRC to the yeast spindle pole body for functional analysis
  • Engineer the gamma-TuRC and study the impact of structural changes on the microtubule system

Requirements

We are looking for a highly motivated and skilled Student Assistant with a Bachelor Degree in a relevant field. The ideal candidate should have experience in molecular biology, biochemistry, or a related field.

What We Offer

The position is available immediately, and the successful applicant will be supported by a Hiwi contract for six-eight months. Heidelberg University stands for equal opportunities and diversity. Qualified female candidates are especially invited to apply. Persons with severe disabilities will be given preference if they are equally qualified.



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