Phd Student
vor 2 Monaten
The University Hospital of Tübingen is a leading center of German university medicine. Every year, around 75,000 inpatients and around 380,000 outpatients are treated. With around 10,000 employees, it is the largest employer in the region. The quality of patient care is certified with the KTQ seal of approval.
Our Image Guided and Functionally Instructed Tumor Therapies (iFIT) research group of Dr. Liudmila Andreeva is looking for a
**PhD student (f/m/d) in structural immuno-oncology**:
The part-time-position (65 %) is available from May 2023 and for 1 year with further extension expected.
The iFIT Cluster of Excellence „Image Guided and Functionally Instructed Tumor Therapies (iFIT)“ is a multidisciplinary research consortium with an ambitious goal - to understand biological processes behind tumors and to develop the next generation cancer diagnostics and therapeutics.
The Andreeva lab focuses on structural and mechanistical aspects of inflammatory pathways underlying human inflammation-associated disorders such as cancer. By using various structural, biochemical and cell-based approaches we aim to explain inflammatory pathways on molecular level and to provide basis and foundation for novel anti-inflammatory and anti-cancer treatments.
**Further reading**:
- NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation- cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders- BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome**Responsibilities**:
- Plan and conduct research experiments including: Large-scale recombinant protein expression and purification using various techniques, electron micsocopy and cryo-electron microscopy to determine molecular structures of the protein complexes, biochemical and biophysical validation of protein complexes, cell culture work- Analyse, interpret and present research results- Develop and demonstrate a thorough understanding of related scientific literature- Contribute to writing research reports, publications and grants**Requirements**:
- Diploma or Master’s Degree (or equivalent) in biology, life sciences or related discipline- Hands-on experience with molecular biology, biochemistry and cell culture techniques are preferred- Attention to details, responsibility and creativity- Excellent organization, communication and documentation skills and excellent English (oral and written)- Strong interest in structural biology and immunity- High levels of self-motivation and an willingness to take up new skills and responsibilities- Ability to work both independently, as well as in a teamWe offer an attractive and versatile workplace in a top institution in Germany, a collaborative and pleasant working atmosphere and an exciting project in a highly dynamic, relevant and rapidly developing field.
**Kontakt bei Fragen**:
**Frau Dr. Liudmila Andreeva**
Tel.: 07071 29-0
**Bewerbungsfrist: 03.03.2023**
Wir freuen uns auf die Bewerbung an **Frau Dr. Liudmila Andreeva**
mit Lebenslauf und Motivationsschreiben unter Angabe der **Kennziffer 2367**.
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