Postdoc - Statistical Analyses of Multi-omics Data

vor 3 Wochen


Munich, Deutschland Klinikum rechts der Isar der Technischen Universität München Vollzeit

**Hospital rechts der Isar (MRI) of Munich Technical University (TUM)**

PostDoc - Statistical Analyses of multi-omics data (M/F/d)

**Full-time / part-time | temporary (24 months) | **Klinik und Poliklinik für Neurologie**

The department focuses on three areas of MS research: imaging, antibodies, and genetics. We have conducted the largest MS genome-wide association study in a single population and thereby discovered new MS risk variants. We have also investigated the influence of genetics on serological (e.g., intrathecal IgG synthesis, immune cell subsets, autoantibodies) and Magnetic Resonance Imaging parameters (e.g., lesion volume, spinal cord, and brain atrophy) related to MS. We aim to extend these studies by integrating additional multi-omics data to understand specific MS phenotypes and the disease progression in MS better.

**Your tasks**:

- Integrate genetic, clinical, and other phenotypic data with multi-omics
- Integrate genetic with clinical data from structured electronic medical records
- Design and conduct case/control analyses and analyses of quantitative traits using rare-variant whole-exome sequencing and common-variant microarray genotype data
- Calculate and analyse polygenic risk scores to assess how genetic risk influences clinical variables related to disease severity and to investigate other omics data
- Conduct differential expression and protein-QTL analyses to identify potential MS biomarkers

**Your profile**:

- You are a highly motivated scientist with a Ph.D. or equivalent degree in statistical genetics, genetic epidemiology, bioinformatics, human genetics, or related fields
- You have a strong background in biomedical statistical analyses of whole-exome sequencing and/or imputed genotype data
- Ideally, you have experience in analyses of expression and/or mass spectrometry data, e.g., differential expression analyses
- You have very good programming skills in R or Python and are familiar with PLINK and related tools
- You are familiar with high-performance computing via a Linux terminal
- You show a strong commitment, motivation, and discipline to work independently and efficiently
- You are a strong team player with the ability to work together with colleagues from various disciplines
- You show an excellent ability to communicate, present, and write in English
- You have experience in publishing scientific findings

**We offer you**:

- A versatile and exciting position in the neuroimmunological research group, consisting of international scientists and physicians
- Outstanding international research environment
- Excellent infrastructure for research in an attractive, versatile workplace
- Access to national and international research networks
- Flexible working hours
- A place of work in the center of Munich at Max-Weber-Platz, with excellent accessibility via public transport and discounted job tickets
- Payment based on the German TV-L E13 scale (100%)

**Contact**: Ms. Brigitte Süß | 089 / 4140-4601 | Klinik und Poliklinik für Neurologie
- ** reference number 23 01_017**:

- **your preferred starting date.**

Prof. Dr. B. Hemmer
Klinikum rechts der Isar der Technischen Universität München
Klinik für Neurologie
Ismaninger Straße 22
81675 München



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