Phd Position

vor 4 Wochen

Munich, Deutschland Technische Universität München Vollzeit

**Job description**
This fully-funded PhD project (project P02 of the CRC1371) is based on work from the first funding period that identified the X-linked inhibitor of apoptosis protein (XIAP) as an important regulator of small-intestinal homeostasis. XIAP functions as an inhibitor of microbiota, TNF-, and RIPK3-dependent death of Paneth cells and myeloid cells, specifiable in the terminal ileum of mice. In the absence of XIAP, Paneth cells are dysfunctional, which is associated with defects in control of the microbiota and susceptibility to bacteria able to promote intestinal inflammation in these genetically susceptible hosts. Inflammatory cell death of myeloid cells in the absence of XIAP contributes to the release of cytokines such as TNF, which further promotes Paneth cell dysfunction, thus supporting a self-reinforcing pathway of inflammation. Together, these findings illustrated how genetic defects associated with Paneth cell dysfunction can elicit susceptibility to microbial drivers of inflammation. In addition, our work highlighted host and microbial targets for therapeutic interference with intestinal inflammation in XIAP deficiency and potentially other genetic alterations associated with Paneth cell dysfunction.

Based on these data, in the next funding phase, we will further delineate host and microbial requirements for promotion of intestinal inflammation in XIAP-deficient mice and aim to develop bacterial consortia for the prevention and treatment of intestinal inflammation in XIAP deficiency. This work will be complimented with studies on patient-derived studies focused on microbial drivers of disease. For more detail, please take a look at our publications Wahida, Müller et. Al., (2021) Sci. Immunology (10.1126/sciimmunol.abf7235) and Strigli et al., (2021) Sci. Immunology (10.1126/sciimmunol.abf7473).

**Required qualification**

**Salary and duration**

**Application deadline**
Applications will be considered until all positions are filled.

**Contact person**

**Application**
Applicants are asked to send one pdf file to the contact person. The file includes
1. cover letter,
2. curriculum vitae,
3. copies of academic degrees and transcripts of records,
4. preferences of projects (optional),
5. contact information for at least one letter of recommendation,
6. list of publications with link for downloading (Do not include your publications in the pdf file).

**Data Protection Information**:
**Hinweis zum Datenschutz**:
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