Phd Student
vor 2 Wochen
Employer
Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
Location
Bonn, Nordrhein-Westfalen (DE)
Salary
TVöD Bund
Closing date
15 Mar 2024
Discipline
Biomedicine ,
Clinical ,
Life Science
Job Type
PhD Studentship
Employment - Hours
Full time
Duration
Fixed term
Qualification
Masters
Sector
Academia
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PhD Student (f/m/x) in Microglia Biology in Alzheimer’s
Code 1283/2024/2
The Capasso lab is interested in how myeloid immune cells change with age and the impact this has on neurodegenerative diseases.
We are studying proteins regulating immune cell activation and how their loss can affect microglia response to amyloid plaque deposition, a hallmark of Alzheimer’s pathology. One of these proteins is the voltage-gated proton channel HVCN1, expressed by microglia and other immune cells. HVCN1 regulates immune cell ROS production (Capasso et al., Nature Immunology, 2010; Hondares et al., PNAS, 2014; Coe et al., JCI Insight, 2022) and we are investigating the effect of its loss in Alzheimer’s mouse models
Your tasks
We are seeking a PhD student with a strong interest in neurodegeneration who wants to study molecular aspect of microglia phenotypes as well as in vivo behavior in preclinical models.
**Requirements**:
We offer
An interesting and challenging task in a research center that works on the future topics of health research
An international environment characterized by a strong focus on science and research
Options for the realization of family-friendly and flexible working conditions
Targeted personnel development
Initially limited to 2 years, with the possibility of extension
Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst - TVöD Bund).
You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE.
**Application deadline**: 15.03.2024
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