Postdoc in Molecular Neurodevelopmental Research

vor 2 Monaten

Mainz, Deutschland Institut für Molekulare Biologie gGmbH Vollzeit

**About us**:
**Background**

Human brain development is spatially and temporally tightly controlled, with sequential and precise orchestrated cellular and molecular programs. Any perturbation in these progresses can lead to detrimental effects. For example, mutations in genes encoding for epigenetic regulators, especially for the BAF chromatin remodeling complexes, are frequently causative for neurodevelopmental disorders. These manifest in brain abnormalities, intellectual disabilities and other physical aberrations. We still hardly understand the molecular mechanisms during human brain development that are mediated by these regulators and how their mutations manifest into the disease phenotypes.

BAF chromatin remodeler complexes are large multi-subunit complexes that can slide or eject nucleosome and thereby regulate chromatin accessibility and ultimately gene expression. Recently, we have shown that the maintenance of chromatin accessibility requires constant BAF complex activity and that perturbation of their function during brain development can result in severe molecular, cellular and phenotypic alterations.

**The position**:
**Deciphering the role of BAF complexes in human brain development and neurodevelopmental disorders**

As part of the chromatin regulation group, you will be working on a project addressing the role of BAF chromatin remodelling complexes in human brain development and related diseases. As a model system, you will use the differentiation of human induced pluripotent stem cell (hiPSC) into brain organoids in combination with genetic and pharmacological perturbations. Advanced cell and molecular biology techniques, including CRISPR screen, bulk and single cell genomics, proteomics and microscopy, will be used to unravel the cellular and molecular mechanisms driven by BAF chromatin remodelers. The project will be funded by the European Union (ERC Starting Grant).

**Tasks and responsibilities**:

- hiPSC culture and organoid differentiation
- Planning, optimization and execution of various state-of-the-art molecular and cellular biology methods
- Data analysis, documentation and presentation
- Regularly participate and present at (internal) meetings
- Study of relevant scientific literature

**Requirements**:

- Highly motivated and creative researcher who enjoys bench-work
- Experience in cell culture techniques is highly beneficial
- Enthusiasm about science especially with regard to neurodevelopmental processes, gene regulation and epigenetics
- Ability to work precisely and good attention to detail
- Ability to work independently after an initial training period as well as in a team
- Very good oral and written communication skills in English
- Computational skills are an asset but not compulsory

**Why join us?**:
We offer a stimulating, diverse and international research environment, with a pleasant working atmosphere and the opportunity to perform state-of-the-art experiments. The institute is modern, well-equipped and centrally located with good public transport links and parking.

**Our offer**:

- Competitive salary and favourable pension scheme
- Advanced training opportunities
- Flexible working hours
- Job Ticket
- Employee events
- Being part of the ERC Starting Grant “SWItchFate”

**What else you need to know**:
**Starting Date**:January 2025 or later
**Duration**:2 years** **with option of extension
**Deadline**:30th November 2024

**Have we sparked your interest?**:

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