Phd Position

**Better together. For life.**

At the University Medical Center Hamburg-Eppendorf (UKE), we are committed to excellence in research, education, and comprehensive healthcare across our clinics. Every day, our team of approximately 15,300 dedicated employees works to make the world a healthier place. Our goal is to be one of the leading university hospitals while also being the best employer in our industry.

At UKE, we believe that meaningful and successful work should align with our employees' personal needs and individual lifestyles. Just as diverse as these needs are, so too is the variety of personalized solutions we offer.

**Welcome to the UKE.**

**PhD position / Junior Research Associate (all genders) in the field of Nephrology**:
**Job-ID**:
J000004575

**Contract Type**:
Temporary

**Employment Type**:
Part time

**Closing Date**:
16.06.2025

**Organization**:
UKE_Zentrum für Innere Medizin

**Category**:
Research & Science

**Department**:
III. Med. Klinik (Nephrologie)

**Main tasks**:**

Our research group investigates various kidney diseases, with a particular focus on glomerular damage and the resulting conditions that can lead to chronic kidney failure. This project explores approaches for cell-specific gene therapy in the glomerulus using adeno-associated viral vectors (AAV).

In this project, we will utilize available tools to modify the AAV capsid surface e.g. by displaying single-domain antibodies. This strategy aims to improve the specificity and efficiency of transgene delivery to glomerular cells. The AAVs generated in this project will be used for the for the targeted delivery of therapeutic genes, with the aim of treating glomerular diseases such as glomerulonephritis by modulating inflammatory processes.

This position is part of our graduate program within the Collaborative Research Center SFB1192. The research group is international and interdisciplinary. The working environment is state-of-the-art and located on the newly opened Campus Research II.

**Main tasks**:

- Production of AAV variants
- Functional analysis of AAV specificity
- Development of gene therapies using AAVs for glomerular kidney diseases
- This position is initially limited to three years in accordance with WissZeitVG as well as due to third-party funding and is to be filled at 65% of the regular weekly working hours.

**Your Profile**:**
- Completed university degree (Master’s or equivalent) in Biology, Biotechnology, Human Biology, Life Sciences, or a comparable field
- Strong interest in scientific research, particularly in gene therapy
- Commitment to conducting mouse experiments
- Proficiency in basic molecular biology techniques (e.g., cloning, PCR, cell culture);
experience with adeno-associated virus (AAV) production and handling highly desirable
- Excellent command of English, given the international nature of the research group
- Team spirit, flexibility, and enthusiasm for scientific work

**Immunity status**:**

Please note that employment is contingent upon proof of immunization or immunity against the measles virus, in accordance with applicable legal and medical requirements. Documentation (e.g., vaccination certificate) must be provided before employment begins.

**Our Offer**:**
- Attractive compensation according to **TVöD/VKA**:

- Secure employment with meaningful work and respectful collaboration
- Comprehensive onboarding and open knowledge exchange within the team
- Extensive training and further education programs at our **UKE Academy for Education and Careers**:

- Opportunities to contribute to our “UKE INside” personnel policy through cross-professional and cross-hierarchical projects
- Sustainable travel: subsidies for the Deutschlandticket as a job ticket, and Dr. Bike bicycle service
- Family-friendly working environment: cooperation on childcare, free vacation childcare, advice for employees with relatives in need of care
- Excellent health, wellness, and sports programs
- A wide range of dining options in our staff restaurant, with additional choices available at the “Health Kitchen” cafés, bistros, and an on-site supermarket

**Contact**:**

**Contact to the department**:
**Dr. Nicole Wanner**:
**Recruiting contact**:
**Recruiting Team**:
**+49 (0) 40 7410-52599**

**About us**:**

**We live diversity and value variety**

We offer a work environment that provides equal opportunities regardless of age, gender, sexual identity, disability, ethnic and social origin, or religion. This is confirmed by our accession to the Charter of Diversity. We explicitly aim to increase the proportion of women in management positions, especially among scientific personnel in research and teaching. Women with equal qualifications will be given priority. The same applies in the case of under-representation of one gender in the advertised area. Persons with severe disabilities with equal aptitude, competence, and professional performance will be given priority.

**Employer**:**

Erstes gesamtzertif