Master Thesis: Evaluation of Activity of New Sesquiterpenoid Modulators On The Trpv1 Ion Channels and Their Role in Neuronal Chemoreception

Vor 3 Tagen


Erlangen, Deutschland Friedrich-Alexander-Universität Erlangen-Nürnberg Vollzeit

Biointerfaces Lab is offering **Ihre Aufgaben**: The thesis will include evaluation of solubility and biocompatibility of caryophyllene, caryolanol and three caryolanol derivatives (acetate, amide and thiol), followed by the dose-response study of the TRPV1 activity isolated in HEK293 cells. If the time allows, the model system will be evaluated in primary neurons. The new Sesquiterpenoid modulators are derivatives of caryolanol, which is formed in the body during digestion from caryophyllene and modulates GABAA receptors. Caryolanol and its derivatives could also be promising modulators of the TRPV1 ion channel and may have important role in controlling neuronal processes, such as pain reception. **Ihr Profil**: **Anmerkung**: Für alle Stellenausschreibungen gilt: Die Friedrich-Alexander-Universität fördert die berufliche Gleichstellung der Frauen. Frauen werden deshalb ausdrücklich aufgefordert, sich zu bewerben. Schwerbehinderte im Sinne des Schwerbehindertengesetzes werden bei gleicher fachlicher Qualifikation und persönlicher Eignung bevorzugt berücksichtigt, wenn die ausgeschriebene Stelle sich für Schwerbehinderte eignet. Details dazu finden Sie in der jeweiligen Ausschreibung unter dem Punkt "Bemerkungen". Bei Wunsch der Bewerberin, des Bewerbers, kann die Gleichstellungsbeauftragte zum Bewerbungsgespräch hinzugezogen werden, ohne dass der Bewerberin, dem Bewerber dadurch Nachteile entstehen. Ausgeschriebene Stellen sind grundsätzlich teilzeitfähig, es sei denn, im Ausschreibungstext erfolgt ein anderweitiger Hinweis. - Veröffentlichungsdatum: 24.09.2025_, **Bewerbungsschluss**: 31.12.2025 **Titel** - Master Thesis: Evaluation of activity of new Sesquiterpenoid modulators on the TRPV1 ion channels and their role in neuronal chemoreception**Einstellungstermin** - 15.09.2025**Ort** - Department Chemie und Pharmazie Henkestrasse 91 91052 Erlangen**Arbeitszeit** - Vollzeit**Wochenarbeitszeit** - Nach Vereinbarung**Befristung** - Befristete Anstellung**Kontakt** - Juniorprofessur für Sensory Sciences (am Chair for Aroma und Smell Research) - Telefon: +49 9131 85-25859



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