Phd Student

vor 2 Wochen

Göttingen, Deutschland Klinik für Kinder- und Jugendmedizin Vollzeit

Ihre Aufgaben
- Investigate the molecular mechanisms underlying childhood-onset neurometabolic and neuroinflammatory diseases, with a focus on X-ALD.
- Identify and validate biomarkers for early diagnosis and differentiation of disease courses.
- Explore oxidative stress and mitochondrial dysfunction as aspects of disease progression.
- Use patient-derived cell lines, cellular models, as well as the X-ALD mouse model for pathophysiological studies.
- Develop and refine high throughput suitable assays for drug repurposing screenings in collaboration with the DZKJ Screening Program.

Ihre Qualifikationen
- A Master’s degree either in Neuroscience, Medicine, Molecular Biology, Biochemistry, or a related field.
- Hands on skills for experimental work in neurobiology, molecular biology, or biochemistry.
- Experience with cell culture techniques.
- Interest in learning gene editing in iPSC culture and work with mouse animal models is encouraged.
- Highly motivated, team-oriented, and able to work independently.
- Excellent communication skills and proficiency in english.

Wir bieten
- an attractive and supportive work environment within the Göttingen Neurosciences, including collaborations with esteemed institutions such as the German Centre for Child and Adolescent Health (DZKJ), German Centre for Neurodegenerative Diseases (DZNE) and the Max Planck Institute for Multidisciplinary Sciences. The working groups are supported by the the German Research Foundation (DFG), the Federal Ministry of Education and Research (BMBF), Horizon Europe and patient organizations.
- a wide range of interesting benefits as an UMG employee (including in-house daycare center, child vacation care, attractive infrastructure; health and sports promoted by excellent company health management)
- location in a beautiful and historic German university town steeped in tradition, with a campus that includes the University of Göttingen, Max Planck Institutes, German Primate Centre and other local research institutions

If you have any questions, please contact Dr. Lara Maleen Marten (lara.marten(at)med.uni-goettingen.de).
Einleitungstext
This exciting research opportunity focuses on the molecular basis and pathogenesis of childhood-onset neurometabolic and neuroinflammatory diseases, particularly rare peroxisomal disorders such as X-linked Adrenoleukodystrophy (X-ALD). The primary goal is to improve diagnostic methods and to develop novel therapeutic strategies for these devastating conditions.
**Research Focus**: Childhood-onset rare neurometabolic disorders represent a complex and heterogeneous array of diseases with overlapping pathophysiological features. These predominantly genetic conditions manifest with symptoms like progressive movement disorders, hearing and vision loss, seizures, cognitive decline and early death if left untreated. Despite their severity, many remain enigmatic at the molecular level, with no effective treatments available.
This project will specifically focus on peroxisomal disorders like X-ALD, with an emphasis on exploring the underlying pathophysiological processes. The key areas of investigation will include the roles of oxidative stress and mitochondrial dysfunction as primary drivers of disease progression.

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