Two Doctoral Positions

vor 1 Woche

Duesseldorf, Deutschland Universität zu Köln Vollzeit

Evolution of Toll´s role for axis formation in insects

Toll signaling is known for its role in innate immunity. However, in

insects Toll is also involved in establishing the dorsoventral body axis.

Our past work suggests that this is an evolutionary novelty of insects.

In the cricket Gryllus bimaculatus, Toll signaling has convergently

acquired a morphogen function comparable to that in Drosophila

melanogaster. We seek two doctoral students to explore the molecu
- lar underpinnings of the striking parallels between DV patterning in

crickets and flies. They will work closely together, one student focu
- sing on protein dynamics and the identification of new genes of the

network, the other focusing on epigenetic methods and cis-regulatory

elements.

**YOUR TASKS**
- CRISPR/Cas mediated genome editing in crickets
- Creating fluorescent protein-tagged transgenes
- Live imaging of morphogen dynamics
- Differential transcriptome analyses (RNA-seq)

for identifying network components
- Mapping open chromatin by ATAC-seq in order
to identify cis-regulatory elements
- Computational analysis of cis-regulatory sequences
- Collaborations with international experts

**YOUR PROFILE**
- Interest in evolutionary developmental biology
- Master‘s degree (or equivalent) in biology, ideally focused on

molecular biology, developmental biology, and/or bioinformatics
- Experience with or high motivation to learn about molecular,
developmental and live imaging microscopic techniques
- Motivation to acquire bioinformatic skills
- Open for lab exchange with our international collaborators

**WE OFFER**
- Interactions with several international research
groups, modern imaging Facility
- Expertise in imaging analysis
- Expertise in NGS methods and data analysis
- Expertise in development and molecular genetics of insects
- A diverse working environment with equal opportunities
- Support in balancing work and family life
- Flexible working time models
- Extensive advanced training opportunities
- Occupational health management offers

The University of Cologne is committed to equal opportunities and
- sidered preferentially in accordance with the Gender Equality Act of

the State of North Rhine-Westphalia (LGG NRW). We also expressly

of equal status.

The position is available from the earliest possible starting date

on a full-time basis The position is to be filled for a fixed term of 3

years. If the applicant meets the relevant wage requirements and

personal qualifications, the salary is based on remuneration group

(65%) 13 TV-L of the pay scale for the German public sector.
- rence number Wiss2303-22.

If you have any questions, please contact

**Two doctoral positions (f/m/x)**

**Siegfried Roth Laboratory - Institute for Zoology**

**We are one of the largest and oldest universities in Europe and one of the most important employers in our region.**
**make us attractive for students and researchers from around the world. We offer a wide range of career opportunities**
**in science, technology, and administration.**

**Faculty of Mathematics and Natural Sciences

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