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vor 16 Stunden


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Ihre Aufgaben - driving experimental projects that study redox modifications in genetically modified induced pluripotent stem cell derived neurons - analyze the consequences of redox modifications for neuron physiology - collaborative work in our research team, for example together with PhD or BSc/MSc students - teaching of undergraduate students in physiology as part of the study programmes human medicine, dental medicine, molecular medicine and cardiovascular physiology Ihre Qualifikationen - enthusiasm for science and interest in understanding redox biology - experience with analyzing protein modifications and analyzing proteome data sets - experience with analyzing neuron physiology - ability to work independently and also in a team - good command of the English language and basic knowledge in German language Wir bieten - work in a stimulating, interdisciplinary and innovative environment within a highly motivated, skilled and international team - salary according to the collective agreement for the public State service (TV-L) including social benefits Einleitungstext Heart failure is one of the most common causes of morbidity and mortality worldwide. At the cell level, the injured heart reacts with complex and stereotypical remodeling processes in cardiomyocytes and in the so-called non-cardiomyocytes (fibroblasts, endothelial cells, immune cells, etc.). Striking changes in these cells are redox-dependent modifications to regulatory proteins. Moreover, heart failure affects brain functionality, which we will address in induced pluripotent stem cell derived models. An imbalance in the production of reactive oxygen species and an altered "redox state" is involved in the development of heart failure but also altered neuronal function. As part of our projects, we develop technical tools for the quantification of redox changes in neurons and cardiomyocytes and their consequences for the function at cell and organ level (see for example doi.org/10.1038/s41467-023-37744-x).


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