PK/PD Module expert: Translational
vor 2 Wochen
The client is seeking an external expert who brings a decision-maker’s mindset — someone who has personally driven translational pharmacology choices under governance and uncertainty. Who we’re looking for Has owned FIH starting dose, SAD/MAD design, and Phase 2 dose selection for multiple assets. Participated in governance or review boards, defending dose/exposure rationale in front of senior leadership or regulators. Demonstrates ability to balance nonclinical → clinical translation: tox, PK, PD, potency, and MoA. Can articulate the real decision calculus behind dose selection (safety, pharmacology, speed-to-proof). Capable of turning narrative judgment into explicit decision rules and rubrics for AI training and evaluation. Experience level ~10+ years in major biopharma or biotech (e.g., Lilly, Roche, AbbVie, Amgen, Novartis, GSK, Regeneron, Vertex, Incyte, Gilead) or in specialized translational pharmacology consulting. Has personally led FIH dose and/or SAD/MAD escalation for ≥2–3 assets. Proven governance experience: IND sign-off, dose justification memos, exposure–response presentations. CV or track record includes statements like “led clinical pharmacology strategy and FIH dose selection” or “accountable for exposure–response in Phase 1/2.” Avoid pure modeling profiles; the ideal expert has decision accountability, not just analytical skill. Expectations Write “golden” FIH dose rationales and escalation strategies for representative programs. Encode the decision heuristics and trade-offs used by senior translational leaders into structured guidance and rubrics. Surface unwritten decision rules — when and why experienced teams override model-based recommendations. Inputs given: Representative drug programs or data packets (GLP tox summaries, PK/PD tables, potency & MoA context). Target prompts for translational decision-making (e.g., “Recommend FIH dose and escalation strategy given these data”). Expected outputs: Golden Decision Memos: exemplar dose justification memos that reflect the level of reasoning and format expected from top-tier translational pharmacologists. Decision Rubrics: scoring guides capturing acceptable vs. unsafe dose rationales, missed edge cases, or failure modes. Meta-Layer Commentary: short narrative explaining unspoken heuristics — how senior teams weigh risk tolerance, potency data, or tox uncertainty.
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PK/PD Module expert: Translational
vor 2 Wochen
Berlin, Berlin, Deutschland Mercor Vollzeit 120.000 € - 180.000 € pro JahrThe client is seeking an external expert who brings a decision-maker's mindset — someone who has personally driven translational pharmacology choices under governance and uncertainty. Who we're looking for Has owned FIH starting dose, SAD/MAD design, and Phase 2 dose selection for multiple assets. Participated in governance or review boards, defending...
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PK/PD Modeling
vor 2 Wochen
Berlin, Berlin, Deutschland Mercor Vollzeit 80.000 € - 120.000 € pro JahrThis person complements the client's "Translational / Clinical Pharmacology Decision-Maker" team by grounding dose selection and exposure–response analysis in quantitative structure and parameter plausibility. Who we're looking for Deep hands-on experience in PK, PD, exposure–response modeling, and ideally population PK or QSP. Expert at model fitting,...
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PK/PD Modeling
vor 2 Wochen
Berlin, Deutschland Mercor VollzeitThis person complements the client’s “Translational / Clinical Pharmacology Decision-Maker” team by grounding dose selection and exposure–response analysis in quantitative structure and parameter plausibility. Who we’re looking for Deep hands-on experience in PK, PD, exposure–response modeling, and ideally population PK or QSP. Expert at model...
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Pharmakometrischer Experte
Vor 2 Tagen
Berlin, Deutschland Bayer Vollzeit**Bei Bayer sind wir Visionär*innen und entschlossen, die größten Herausforderungen unseres Planeten zu überwinden und zu einer Welt beizutragen, in der genug Nahrung und ausreichende medizinische Versorgung für alle Menschen keine unerreichbaren Ziele mehr darstellen. Wir tun dies mit Energie, Neugier und purer Hingabe, lernen stets von den Menschen um...
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Pharmakometrischer Experte
vor 2 Wochen
Berlin, Deutschland Bayer VollzeitBei Bayer sind wir Visionär*innen und entschlossen, die größten Herausforderungen unseres Planeten zu überwinden und zu einer Welt beizutragen, in der genug Nahrung und ausreichende medizinische Versorgung für alle Menschen keine unerreichbaren Ziele mehr darstellen. Wir tun dies mit Energie, Neugier und purer Hingabe, lernen stets von den Menschen um...
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Pharmacometrics Expert
Vor 2 Tagen
Berlin, Deutschland Bayer Vollzeit**At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our...
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Pharmacometrics Expert/ Modeling
vor 2 Stunden
Germany: Berlin or Wuppertal-Aprath Bayer Crop Science Vollzeit 60.000 € - 120.000 € pro JahrAt Bayer we're visionaries, driven to solve the world's toughest challenges and striving for a world where ,Health for all, Hunger for none' is no longer a dream, but a real possibility. We're doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and...
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Clinical Pharmacology Lead
vor 1 Woche
Berlin, Deutschland Bayer Vollzeit**At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our...
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Berlin, Deutschland PD - Berater der öffentlichen Hand GmbH VollzeitPD - Berater der öffentlichen Hand - Berlin - Hamburg - Präsenz / Mobil Wir bieten Ihnen einen Job mit Sinn: / Für die öffentliche Hand von morgen / - Denn: Wir sind Partnerin der Verwaltung und beraten vielfältige Projekte zu **moderner Verwaltungsarbeit** und **Infrastruktur** auf Bundes; - Landes - und kommunaler Ebene. Dabei agieren wir neutral,...
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Oracle EBS expert
vor 1 Stunde
Berlin, Deutschland NetPartners International VollzeitOracle EBS expert About the RoleWere looking for a senior Oracle E-Business Suite (EBS) Functional Expert to join an ongoing rollout. The ideal consultant will have a deep functional understanding of Oracle EBS modules and be able to independently engage with business stakeholders, manage requirements, and drive solution delivery.Candidate MUST be in...
