PK/PD Modeling
vor 2 Wochen
This person complements the client’s “Translational / Clinical Pharmacology Decision-Maker” team by grounding dose selection and exposure–response analysis in quantitative structure and parameter plausibility. Who we’re looking for Deep hands-on experience in PK, PD, exposure–response modeling, and ideally population PK or QSP. Expert at model fitting, sensitivity analysis, and identifying non-plausible parameter spaces. Can evaluate the validity of dose–exposure predictions and detect high-risk extrapolations. Comfortable designing model evaluation rubrics that distinguish between acceptable vs. non-credible outputs. Able to articulate how quantitative checks should complement narrative decision logic. Nice-to-have: Experience supporting translational or clinical pharmacology leads in dose justification. Familiarity with integrating nonclinical PK/PD data (2-species GLP → human FIH extrapolation). Experience level ~8–12 years of quantitative pharmacology experience in pharma, CROs, or modeling consultancies. Strong portfolio in population PK/PD, exposure–response, and parameter estimation using NONMEM, Monolix, or equivalent tools. Demonstrated ability to interpret model results for decision-making, not just fit data. Can create fit-for-purpose models and critique model structures or assumptions under uncertainty. Expectations Design and refine micro-evaluations for PK/PD performance (curve fits, parameter checks, error taxonomies). Encode quantitative sanity checks into model rubrics for automated evaluation. Define failure conditions (e.g., unsafe extrapolation, poor coverage curves, invalid assumptions). Inputs we give: PK/PD datasets, tox summaries, and performance prompts (e.g., “fit exposure–response curves, interpret safety margins”). Example model outputs from automated systems. Expected outputs: Quantitative Rubrics: clear thresholds for acceptable parameter fits, coverage curve quality, and model integrity checks. Golden Fit Examples: representative “ideal” PK/PD model outputs and visualizations for calibration. Error Taxonomy: structured list of typical modeling or fitting errors, with root-cause annotations. Meta-Layer Commentary: short note per rubric capturing how expert modelers recognize implausible or unsafe fits beyond numeric error values. Engagement Model & Compensation Contract / part-time, remote, outcome-based deliverables.
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PK/PD Modeling
vor 2 Wochen
Berlin, Berlin, Deutschland Mercor Vollzeit 80.000 € - 120.000 € pro JahrThis person complements the client's "Translational / Clinical Pharmacology Decision-Maker" team by grounding dose selection and exposure–response analysis in quantitative structure and parameter plausibility. Who we're looking for Deep hands-on experience in PK, PD, exposure–response modeling, and ideally population PK or QSP. Expert at model fitting,...
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PK/PD Module expert: Translational
vor 2 Wochen
Berlin, Berlin, Deutschland Mercor Vollzeit 120.000 € - 180.000 € pro JahrThe client is seeking an external expert who brings a decision-maker's mindset — someone who has personally driven translational pharmacology choices under governance and uncertainty. Who we're looking for Has owned FIH starting dose, SAD/MAD design, and Phase 2 dose selection for multiple assets. Participated in governance or review boards, defending...
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PK/PD Module expert: Translational
vor 2 Wochen
Berlin, Deutschland Mercor VollzeitThe client is seeking an external expert who brings a decision-maker’s mindset — someone who has personally driven translational pharmacology choices under governance and uncertainty. Who we’re looking for Has owned FIH starting dose, SAD/MAD design, and Phase 2 dose selection for multiple assets. Participated in governance or review boards, defending...
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Pharmakometrischer Experte
vor 2 Wochen
Berlin, Deutschland Bayer VollzeitBei Bayer sind wir Visionär*innen und entschlossen, die größten Herausforderungen unseres Planeten zu überwinden und zu einer Welt beizutragen, in der genug Nahrung und ausreichende medizinische Versorgung für alle Menschen keine unerreichbaren Ziele mehr darstellen. Wir tun dies mit Energie, Neugier und purer Hingabe, lernen stets von den Menschen um...
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Pharmakometrischer Experte
Vor 2 Tagen
Berlin, Deutschland Bayer Vollzeit**Bei Bayer sind wir Visionär*innen und entschlossen, die größten Herausforderungen unseres Planeten zu überwinden und zu einer Welt beizutragen, in der genug Nahrung und ausreichende medizinische Versorgung für alle Menschen keine unerreichbaren Ziele mehr darstellen. Wir tun dies mit Energie, Neugier und purer Hingabe, lernen stets von den Menschen um...
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Pharmacometrics Expert
Vor 2 Tagen
Berlin, Deutschland Bayer Vollzeit**At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our...
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Clinical Pharmacology Lead
vor 1 Woche
Berlin, Deutschland Bayer Vollzeit**At Bayer we’re visionaries, driven to solve the world’s toughest challenges and striving for a world where ,Health for all, Hunger for none’ is no longer a dream, but a real possibility. We’re doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our...
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Lab Head
vor 1 Woche
Berlin, Deutschland Nuvisan GmbH VollzeitLab Head (m/f/d) in vitro DMPK at Nuvisan GmbH | softgarden View job here Lab Head (m/f/d) in vitro DMPK Full Time Berlin, Deutschland With Professional Experience 11/25/25 We are seeking a hands-on, scientifically driven leader to head our pre-/non-clinical in vitro DMPK laboratory. You will oversee a team of 2-4 lab technicians, ensure high assay...
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Risk Methodology Specialist
Vor 7 Tagen
Berlin, Deutschland Deutsche Bank Vollzeit**Overview** You will work in an international and diverse environment that encourages an open communication, provides a mature feedback culture and offers employees a wide range of options to balance the requirements of the workplace with their personal and family needs. **Your Key Responsibilities**: - Statistical analyses as part of quantitative credit...
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Risk Methodology Specialist
vor 2 Wochen
Berlin, Deutschland Deutsche Bank VollzeitThe **Risk **division **has the fundamental responsibility to protect the Bank. With group-wide responsibility for the management and control of credit, market, operational and reputational risks, we have a unique vantage point, which allows us a holistic view of our businesses and our clients. Nearly 4,000 employees work together to achieve our ambition to...
