PhD Position in Translational Cancer Immunology Researcher

vor 4 Wochen

Munich, Bayern, Deutschland LMU Klinikum Vollzeit

Research Scope

Our team at LMU Klinikum is seeking a highly motivated PhD researcher to contribute to our clinically oriented research in the field of cancer immunology. The successful candidate will be responsible for antigen profiling of primary acute myeloid leukemia cells using single-cell RNA sequencing and multiparameter flow cytometry.

Key Responsibilities

  • Antigen profiling of primary acute myeloid leukemia cells using single-cell RNA sequencing and multiparameter flow cytometry
  • Evaluation of novel T-cell bispecific antibody constructs for treatment of AML
  • Dissecting resistance mechanisms in hematologic malignancies towards bispecific antibodies and CAR-T cell therapies
  • Daily research methods include aseptic cell culture of cell lines and primary patient material, isolation of peripheral blood and bone marrow mononuclear cells from patients and healthy donors, cytotoxicity assays, co-cultures, immune cell activation and inhibition assays, proliferation analysis, and cytokine screening
  • Advanced flow cytometry
  • Presentation of research findings at national and international conferences

Requirements

  • Master's degree in life sciences, biology, biochemistry, molecular biology, or related disciplines
  • Passion for impact: eager to contribute to clinically oriented research that impacts patient care and treatment outcomes
  • Driven and committed: highly motivated with a dedicated approach to research, demonstrating the ability to work independently and efficiently
  • Team player: collaborative and team-minded, thriving in a multidisciplinary research environment
  • Specialized knowledge: a strong theoretical background in immunology is a plus, and knowledge in biostatistics will be advantageous
  • Technical expertise: experience in flow cytometry and handling primary patient material is an asset

Our Offer

  • Remuneration is based on the Collective Agreement for the Public Sector of the Länder (TV-L) including all allowances customary in the public sector

LMU Klinikum

We are a leading medical research institution dedicated to advancing the field of cancer immunology. Our team is passionate about making a meaningful impact on patient care and treatment outcomes.

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