PhD Researcher

Vor 7 Tagen

Sachsen, Deutschland Helmholtz-Zentrum für Umweltforschung GmbH - UFZ Vollzeit
Job Title: PhD Researcher

We are seeking a highly motivated PhD Researcher to investigate the metabolic interaction within a microbiome model system, focusing on the production of nucleotides. The successful candidate will work in the Department of Molecular Toxicology, contributing to a DFG-funded project that aims to decipher the role of nucleotides in the human microbiome model system SIHUMIx.

Key Responsibilities:
  • Cultivate the SIHUMIx consortium in anaerobic continuous bioreactors and manipulate specific species using the CRISP/CAS approach.
  • Characterize the effects of modified gene expression of selected species on the metabolomic level of the various species and the overall community metabolism using mass-spectrometry-based targeted and untargeted metabolomics and metaproteomics.
  • Integrate the omics-results with bioinformatic approaches and also with the results from genome-based metabolic modelling to identify pathways of metabolic regulation within the various species and in the species-species interaction.
  • Participate in laboratory group meetings, including presentation of results.
  • Present research findings at international conferences and prepare publications in peer-reviewed scientific journals.

Requirements:
  • M.Sc. degree (or near completion) in biochemistry, microbiology, bioinformatics, or related fields.
  • Experience in cultivation of bacteria.
  • Profound knowledge of microbiology.
  • Strong interest in mass-spectrometry-based analysis of metabolites and proteins.
  • Strong interest in bioinformatics.
  • Excellent English skills.
  • Ability to organize and prioritize work efficiently.

About the UFZ:
The Helmholtz Centre for Environmental Research (UFZ) is a leading international competence centre for environmental sciences, with over 1,100 employees. We are part of the largest scientific organisation in Germany, the Helmholtz Association. Our mission is to find a balance between social development and the long-term protection of our natural resources.

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