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Senior Oligonucleotide Synthesis Specialist

vor 2 Monaten


Kulmbach, Bayern, Deutschland LGC Axolabs Vollzeit
Job Title: Scientist – DNA-, RNA- Oligonucleotide Synthesis

We are seeking an experienced and motivated scientist to develop innovative synthetic approaches for complex oligonucleotide formats.

About the Role

This is an exciting opportunity to join our innovative R&D team in oligonucleotide chemistry and contribute to the development of new synthetic routes for complex oligonucleotide formats.

Key Responsibilities
  • Develop innovative synthetic and downstream processing routes for complex oligonucleotide formats, including conjugates with fatty acids, peptides, and antibodies.
  • Collaborate with the team to design and execute experiments that optimize lead oligonucleotide drug candidates, focusing on potency, selectivity, stability, and pharmacokinetic properties.
  • Take on responsibility for customer order projects after a thorough training period.
  • Support the Department Head in project planning, client communication, and report writing.
  • Analyze experimental data, interpret results, and present findings internally, to customers, or at international conferences. Contribute to technical reports and manuscripts for publication in peer-reviewed journals.
  • Guide and coach junior staff members in the oligonucleotide synthesis laboratory.
Qualifications
  • Hands-on experience in oligonucleotide synthesis via automated solid-phase methodologies, complemented by a Ph.D. in Chemistry or Biochemistry, or equivalent experience.
  • Prior experience in ligation chemistry (enzymatic and/or chemical) is desired.
  • Proficient in conjugation and purification technologies, with expertise in HPLC, LC-MS, UV spectroscopy, and endotoxin measurement and control.
  • Strong oral and written communication skills in English, ideally also in German, with a keen ability to maintain detailed lab notebooks and reports.
  • A reliable, dedicated working style characterized by a focus on quality, dedication, and excellent communication skills.
What We Offer
  • Comprehensive onboarding and mentoring for a successful start.
  • Permanent employment contract.
  • Responsible tasks and individual development and career opportunities in an innovative, international company.
  • An open corporate culture that values integrity, respect, and a passion for forward-thinking, creative solutions.
  • Company pension scheme and attractive employer subsidies, such as JobRad, as well as corporate benefits.
  • Extensive employee offerings related to health management, as well as online options for childcare and educational support.
  • 30 days of annual leave.
  • Relocation assistance for candidates from outside the region.
  • 100% coverage of the Jobticket (Deutschlandticket) or a free parking space in the adjacent parking garage.

We look forward to receiving your application in English.