Postdoctoral Research Scientist in Molecular Cancer Biology

vor 2 Wochen


Berlin, Berlin, Deutschland MDC Vollzeit
Postdoctoral Research Associate in Molecular Cancer Biology

The research group of Jan Dörr at the ECRC, Charité and Max Delbrück Center for Molecular Medicine, is seeking a highly motivated postdoctoral research associate to join our team in molecular cancer biology.

About the Position

We are an interdisciplinary and international team of enthusiastic scientists and doctors, working on the investigation of causes and consequences of tumor heterogeneity and treatment resistance in pediatric cancers. Our laboratory has generous access to state-of-the-art equipment by the facilities of the Charité and the MDC, with multiple opportunities for translational pediatric cancer research. The working language is English.

Responsibilities
  • Develop research projects in close cooperation with other research groups of the collaborative research center CRC1588:Decoding and Targeting Mechanisms of Neuroblastoma Evolution
  • Define the impact of genetic and phenotypic tumor heterogeneity on therapy resistance in neuroblastoma cell lines, patient-derived xenografts (PDX) and patient samples before and after treatment with cytotoxic or targeted therapies
  • Conduct cutting-edge research in a protected, interactive, highly collaborative, and well-funded environment
  • Collaborate with research groups of the CRC, especially the Mertins group (Max Delbrück Center for Molecular Medicine), and international collaborations (Hondele group, Biozentrum Basel, Switzerland)
Requirements
  • Recent graduate (PhD) or postdoctoral research scientist in cancer biology, biochemistry or molecular medicine
  • Curious, motivated, creative and independent mindset
  • Strong publication record and ambition to pursue an academic career
  • Trained in methods to analyse cell lines by functional genomics (CRISPR-Cas9-based or shRNA-based screenings), molecular biology (PCR, FISH, cloning, immunoblotting, co-immunoprecipitation, proximity labeling, etc.) and molecular medicine (histopathology, flow cytometry, fluorescence microscopy)
  • Proficiency in transcriptomic and proteomic data analyses and basic knowledge in programming (preferably in R)
  • Ability to work in a team within the laboratory and with (inter)national partners and to communicate scientific concepts and data in English
About the MDC

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association is one of the world's leading research institutions for molecular medicine. Our mission is to understand the molecular mechanisms of disease and to develop new therapeutic approaches. We are an interdisciplinary and international team of scientists and doctors, working on the investigation of causes and consequences of tumor heterogeneity and treatment resistance in pediatric cancers.



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