Staff Scientist
vor 2 Wochen
The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) is seeking a highly skilled Staff Scientist to join its Mass Spectrometry and Proteomics technology platform. The successful candidate will be responsible for optimizing and applying various quantitative proteomic methods, including SILAC, TMT, and label-free approaches with DDA and DIA.
Key Responsibilities:- Optimize and apply different quantitative proteomic methods, including SILAC, TMT, and label-free approaches with DDA and DIA.
- Optimize and apply different structural and chemical proteomic methods, such as cross-linking MS, proximity biotinylation, and protein stability profiling.
- Analyze post-transcriptional modifications, with a focus on phosphorylation.
- Support users of the MS facility throughout the MS workflow, from sample preparation to data analysis.
- Coordinate with technicians and engineers to maintain and operate the LC/MS instruments.
- Excellent knowledge of different quantitative proteomic techniques.
- Great prior experience with DDA and DIA acquisition and data analysis.
- Expertise in handling LC/MS instruments, particularly Thermo Fisher Orbitrap Tribrid and Exploris mass spectrometers.
- Experience in cross-linking MS or other structural and chemical proteomic methods is advantageous.
- Ability to accurately and reliably document and present scientific data.
- Strong communication skills and proficiency in English.
The Mass Spectrometry and Proteomics technology platform at the FMP consists of an international team of enthusiastic and collaborative scientists, providing MS services to research groups within and outside of the FMP, while also actively developing novel MS acquisition and analysis strategies.
The research scope of the facility includes global quantitative proteome profiling, as well as the identification of post-translational modifications in synthetic peptides/proteins and various organisms. The platform hosts a range of state-of-the-art mass spectrometers, including two Orbitrap Exploris 480, LTQ-Orbitrap Fusion Lumos, one LTQ-Orbitrap Fusion, and one LTQ-Orbitrap Elite, all equipped with nano-UPLC systems.
The successful candidate will work closely with other staff scientists and technical assistants in the facility, ensuring optimized operation of the MS instruments, setting up proteomics experiments, and assisting researchers in interpreting MS data.
What We Offer:We are looking for a highly motivated, responsible, reliable, and flexible scientist who works well independently as well as with others. The candidate should have a PhD degree in analytical chemistry, biochemistry, biophysics, or relevant fields with a strong expertise in mass spectrometry.
The candidate will be responsible for operation and maintenance of the UPLC and MS systems and should be highly experienced in various proteomics approaches, particularly quantitative proteomics with DDA and DIA acquisitions. Candidates with additional expertise in structural and/or chemical proteomics are advantageous.
The candidate is also expected to have a strong interest in methodological development tailored to specific collaborative projects. Proficiency in spoken and written English is required.
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