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Chromatin Research Scientist

vor 2 Monaten


Heidelberg, Baden-Württemberg, Deutschland Embl-Ebi Vollzeit
Position Overview

We are seeking a dedicated and enthusiastic individual to become part of our innovative research initiative centered on the structural and functional analysis of chromatin in archaea. This project is designed to explore the evolutionary trajectory of histone tails from an ancestral archaeal form to eukaryotic organisms, focusing on the significance of these tails in proto-eukaryotic chromatin.

Key Responsibilities:

  • Integrate tail-less histones with either eukaryotic or Asgard histone tails for both in vitro and in vivo investigations.
  • Conduct detailed molecular-level structural and functional analyses.
  • Engage in cryo-electron microscopy (cryo-EM) single particle analysis of nucleosomes.
  • Perform focused ion beam (FIB) milling of archaeal cells.
  • Utilize cryo-electron tomography (cryo-ET) and subtomogram averaging techniques for chromatin fiber studies.

This role will require collaboration with the laboratory of Naomichi Takemata, fostering regular communication and scientific exchange with our research partners.

Qualifications
  • PhD in structural biology, molecular biology, biochemistry, or a related field (or nearing completion).
  • Experience with cryo-EM/cryo-ET data acquisition and processing.
  • Strong background in biochemistry, including protein expression, purification, and characterization of DNA-protein complexes.
  • Proficiency in command line operations.
  • A genuine passion for the research area, along with high motivation and dedication.
  • Ability to work both independently and as part of an international team.
  • Excellent communication and presentation skills, with fluency in English.
Preferred Skills
  • Experience in microbiology and working with anaerobic microorganisms.
  • Basic programming knowledge.
  • Familiarity with high-performance computing (HPC).