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Postdoctoral Scientist in Tumor Evolution Studies

vor 3 Monaten


Heidelberg, Baden-Württemberg, Deutschland Deutsches Krebsforschungszentrum (DKFZ) Vollzeit

Our mission at the German Cancer Research Center is to contribute to a future free from cancer. We delve into the intricacies of cancer development, identify risk factors, and explore innovative prevention strategies. Our goal is to enhance diagnostic precision and improve treatment outcomes for cancer patients. Every role, whether in research, administration, or support, plays a vital part in this meaningful endeavor.

The Division of Regulatory Genomics and Cancer Evolution, led by Prof. Dr. Duncan Odom, is currently in search of a

Postdoctoral Researcher in Cancer Evolution Mechanisms

Reference number: -

  • Full-time position
  • Location: Heidelberg
  • Focus: Regulatory Genomics and Cancer Evolution

LAB PHILOSOPHY: The Odom laboratory employs state-of-the-art experimental genomics techniques, including spatial transcriptomics and advanced sequencing methods, to investigate mutagenesis, cancer initiation, and progression. We adopt a collaborative approach, working alongside computational research teams across Heidelberg.

Your Responsibilities

PROJECT DESCRIPTION: We are looking for a candidate to lead a team of skilled technicians in a comprehensive analysis of how sex influences mutagenesis and the onset of cancer. This project builds on our innovative use of chemical carcinogens to study cancer initiation in murine models. Initial findings have uncovered a novel cancer formation mechanism termed lesion segregation and have provided insights into the interplay of repair and damage at a single-strand level. This initiative will involve creating and analyzing cancer genomes from female mice and utilizing a four core genotypes model to disentangle the effects of hormones and sex chromosomes. By leveraging advanced spatial mapping of single-cell transcriptomes, we aim to understand how the sex-specific microenvironment influences tumorigenesis.

KEY DUTIES: The successful candidate will need to demonstrate strong leadership skills to coordinate the Odom laboratory technicians and computational collaborators, potentially including clinical partners, into a cohesive research team. Responsibilities will encompass project management, method development, optimization, and the collection and analysis of extensive genomic datasets. Our training in this multidisciplinary environment is designed to foster scientific independence, leadership, and professional growth.

Your Profile

IDEAL CANDIDATE: We seek a postdoctoral research fellow with a strong experimental focus and extensive expertise in molecular biology and genomics. The ideal candidate will be collaborative, ambitious, detail-oriented, scientifically curious, and driven by a desire to explore new frontiers. Experience in single-cell methodologies, transcriptional regulation, cancer genomics, epigenetics, evolutionary biology, bioinformatics, or comparative genomics is advantageous. We also welcome applications from accomplished graduate students looking to transition into this research area.

What We Offer
  • Exceptional working conditions with access to cutting-edge equipment and opportunities for international networking
  • Competitive remuneration in accordance with TV-L, including a company pension scheme and capital-forming benefits
  • 30 days of annual leave
  • Flexible working hours
  • Options for part-time employment
  • A family-friendly work environment
  • Subsidized travel options for commuting
  • A comprehensive Corporate Health Management Program focused on your well-being
  • Opportunities for personal development through the DKFZ International Postdoc Program and DKFZ Career Service

Contact:
Prof. Dr. Duncan Odom

This position is initially limited to a duration with the possibility of extension.

Are you interested?

Join us at the DKFZ and contribute to our mission of advancing cancer research.

We believe that a diverse workforce enhances innovation and creativity. Therefore, we encourage applications from talented individuals of all backgrounds, regardless of gender, nationality, ethnicity, sexual identity, physical ability, religion, or age. Individuals with severe disabilities will be given preference if they possess the same qualifications.

Notice: We adhere to the regulations of the Infection Protection Act (IfSG), requiring all employees to provide proof of immunity against measles.