Phd Position On Inflammatory Bone Loss
vor 6 Monaten
The Department of Orofacial Orthopedics (Prof. Dr. Lina Gölz) of the Uniklinikum Erlangen in collaboration with the Department of Medicine 3 (Prof. Dr. Stefan Uderhardt) offer a PhD position in the joint project “Histocytometric and molecular assessment of the inflammatory osteoclastogenic niche in situ” within the Transregio TRR369 “Degeneration of bone induced by inflammation - DIONE”.
In our clinics, we care for patients suffering from various chronic inflammatory diseases. Pathological inflammation is often accompanied by collateral tissue destruction, e.g. bone erosion, which can lead to structural disabilities or even complete loss of function of the affected tissue in patients. The aim of this project is to understand the mechanisms that lead to emergence of bone-resorbing osteoclasts in model systems for destructive autoimmune diseases such as inflammatory arthritis and periodontitis. To this end, we will perform transcriptome profiling of immune and non-immune cells during disease progression and use state-of-the-art whole tissue optical imaging and novel AI-driven analysis techniques (3D histocytometry) to probe deep into the tissues and decipher the cellular and molecular processes behind pathological osteoclast formation in situ and in vivo as well as bone remodeling in general.
**Your tasks**:
established model systems for inducible arthritis or periodontitis
quantitative imaging combined with AI-driven analysis techniques
transcriptomic analyses
**Essential experience/ qualifications**:
**Additional advantages**:
Experience in bioinformatics, imaging techniques as well as mouse models would be advantageous
**We offer**:
A secure, interesting position as part of a motivated, open team
A well equipped lab with access to the newest technologies (e.g. light sheet microscopy, multiplex imaging, computational facilities, transcriptomics)
A motivated surrounding embedded in the Transregio TRR 369 DIONE
A thorough and qualified induction, and support in your new challenge
A structured educational PhD program (graduate school of TRR DIONE)
Varied and responsible tasks with individual opportunities to grow and develop as a professional
All public service benefits, including supplementary benefits from the Federal and State Government Pension Fund (VBL)
Pay grade is determined depending on qualifications and personal requirements according to TV-L
We seek to employ at the earliest possible starting date
Wir zählen zu den besten Krankenhäusern Deutschlands und sind einer der größten Arbeitgeber in Mittelfranken. Diesen Erfolg erarbeiten tagtäglich unsere über 9.600 hoch qualifizierten Beschäftigten in unterschiedlichsten Berufen. Wir als Uniklinikum Erlangen wissen, dass alle unsere Beschäftigten wichtig sind, damit auch in Zukunft modernste Medizin, ausgezeichnete Forschung und Patientenversorgung auf höchstem Niveau gelingen.
Wenn Sie sich eine Tätigkeit mit einem hohen sozialen Wert wünschen und die Welt der Spitzenmedizin mit uns gemeinsam gestalten und ermöglichen möchten, dann sind Sie bei uns richtig
Hinweise zu Impfungen Das UKER als Arbeitgeber
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