Ph.d. Student

vor 2 Wochen


Munich, Deutschland Klinikum der Universität München Vollzeit

Campus Innenstadt
- WORKING HOURSFull time
- DEPARTMENTKlinik und Poliklinik für Frauenheilkunde und Geburtshilfe
- DEPARTMENTResearch Lab
- DATE OF ENTRY01.05.2023
- APPLICATION DEADLINESwift
- REFERENCE NUMBER2023-K-0269

The Hospital of the University of Munich, Germany, is one of the largest and most competitive university hospitals in Germany and Europe. 48 specialized hospitals, departments and institutions harbouring excellent research and education provide patient care at the highest medical level with around 11.000 employees.

Scope of duties

As part of the BMBF-funded project within European Consortium OVA PDM "Personalising the clinical decision making in ovarian cancer through patient-derived in vitro models" we are searching at the earliest possible date motivated Ph.D. student (M/F/d) 65% (TV-L)

Scope of the study:

- Identification of novel specific biomarkers of PARP inhibitors (PARPi) response, based on analysis of patient-derived organoids (PDOs) from high-grade serous ovarian cancer (HGSOC).
- We will generate a set of PDOs from primary tumor deposits from tumors with known underlying defects in homologous DNA repair (HDR) and analyze cellular hallmarks of the response to PARPi with advanced OMICs methodology (transcriptomics and proteomics) as well as mechanistic studies of the key genes involved in the process
- Lab work will combine 3D organoid culture with the implementation of advanced tools of genomic editing (CRISP/Cas9) and molecular biology, assay development, and high-resolution imaging.

Our requirements
- M.Sc. in biology, biomedicine, molecular biology, or related disciplines
- Experience in primary cell culture work, ideally in work with organoids is desirable
- Strong theoretical background in cell biology, developmental biology as well as molecular carcinogenesis is a plus
- Motivated and dedicated approach to research and ability to work independently

**Offer**:

- We offer vibrant and interdisciplinary working enviroment at the intersection between basic science and clinical research
- Opportunity for networking and exchange of knowledge through interaction with renowed experts within interdisciplinary OVA-PDM consortium
- Salary based on German public service scale (65%)
- Remuneration is based on the Collective Agreement for the Public Sector of the Länder (TV-L) including all allowances customary in the public sector.

Offers and services of the employer

Further education and training

Company pension scheme

Childcare services

Mobile work (if suitable)

Job ticket

Discounts

Staff accommodation

**Dr. rer. nat Mirjana Kessler**:
089 4400 54217

Application format

Disabled persons will be preferentially considered in case of equal qualification. Presentation costs cannot be refunded.



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