Phd Position

vor 3 Wochen


Munich, Deutschland MGZ Vollzeit

**About us**:
The Medical Genetics Center (MGZ) is a specialist practice and accredited laboratory for human genetics in Munich. Founded in 2000, MGZ is one of the leading providers in the field of medical human genetics in Germany with its team of 20 physicians and more than 160 employees.

**Project description**:
We are seeking a highly motivated and skilled bioinformatics PhD student to join our research team for a project focused on advancing the early detection of tumors using non-invasive methods.
Current targeted approaches for circulating tumor DNA (ctDNA) detection are limited by their focus on specific hotspot variants, restricting their applicability to patients with those variants. In contrast, untargeted, genome-wide ctDNA approaches can benefit all cancer patients, regardless of specific somatic variants. Various untargeted methods have been developed to expand the utility of ctDNA analysis to a broader patient population, including the analysis of SCNAs, cfDNA fragmentation profiles, and epigenetic signatures. To this end, we previously developed an integrated workflow for untargeted ctDNA detection called LIFE-CNA (**LI**quid biopsy **F**ragmentation, **E**pigenetic signature, and **C**opy **N**umber **A**lteration analysis), consolidating multiple untargeted ctDNA analysis approaches (Hallermayr et al, 2022).

**Relevant works**:
**Your responsibilities**:

- Develop and implement bioinformatics algorithms to analyze ctDNA data generated from NGS
- Collaborate with researchers and clinicians to validate and interpret the results
- Contribute to the development of machine learning models for improved detection and classification of ctDNA
- Preparation of manuscripts
- Present your work at conferences

**Your profile**:

- A master's degree in bioinformatics, computational biology, or a related field
- Proficiency in Python, CWL, R and command line.
- Experience with genomic data and NGS analysis
- Experience with machine learning techniques/software or a willingness to learn
- Experience with circulating tumor DNA analysis is a plus but not required
- Very good communication and writing skills
- Fluency in German and English is required

**What we offer**:

- The opportunity to work with the latest molecular genetic techniques in a clinical setting
- Long-term perspective with a high degree of creative freedom at one of the leading, owner-managed genetics laboratories in Germany
- Collaboration in an innovative and interdisciplinary team
- Responsible and varied tasks
- Additional benefits for employees, such as coffee and tea, daily fresh fruit and juices, company parties, etc.

**Application Instruction**:
**Über uns**:
Das MGZ - Medizinisch Genetische Zentrum ist eine Facharztpraxis und ein akkreditiertes Labor für Humangenetik mit Sitz in der Münchner Innenstadt. Das im Jahr 2000 gegründete MGZ gehört mit seinen mehr als 170 Mitarbeitern in Deutschland zu den führenden Unternehmen im Bereich der Humangenetik.



  • Munich, Deutschland Technical University of Munich Vollzeit

    PhD Student position in immunology 31.12., Wissenschaftliches Personal A PhD student position is offered as part of the CRC "Control and plasticity of cell-fate decisions in the immune system ( in the Department of Infection Immunology headed by Prof. Christina Zielinski at the Leibniz-HKI. The department of Infection Immunology addresses...


  • Munich, Deutschland Helmholtz Zentrum München Vollzeit

    : Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world. Are you interested in Epigenetics and in crossing borders? Come and join us for our fully funded collaborative 3-year PhD programme “EpiCrossBorders”, the International Helmholtz Munich -Edinburgh Research School...


  • Munich, Deutschland Technical University of Munich Vollzeit

    PhD position: Physics-based and AI-Driven Spectral Imaging for Brain Surgery 02.05., Wissenschaftliches Personal A PhD position within an EIC Pathfinder Project (HyperProbe) focusing on the development of spectral unmixing approaches for identifying biomarkers of brain activity. The lab for Artificial Intelligence in Medicine (


  • Munich, Deutschland Technische Universität München Vollzeit

    **The Engineering Risk Analysis Group at TUM is looking for a PhD student in the area of Model reduction for structural reliability analysis** About us: Your profile: - M.Sc. degree in Applied Mathematics or Civil, Mechanical, Aerospace, or Electrical engineering, or another relevant field. - Excellent grades in courses on numerical methods for partial...

  • Phd Position

    vor 4 Wochen


    Munich, Deutschland Klinikum rechts der Isar der Technischen Universität München Vollzeit

    **Hospital rechts der Isar (MRI) of Munich Technical University (TUM)** **PhD Position (M/F/d) - Hematology/Oncology** **Part-time | temporary (24 month) | **Department of Interal Medicin III** For more information on group's research focus, check the lab homepage: **Your responsibilities**: - Work with a collaborative spirit within at Research Unit at...


  • Munich, Deutschland Technische Universität München Vollzeit

    The Machine Learning and Information Processing group at TUM works at the intersection of machine learning and signal/information processing with a current focus on deep networks for solving inverse problems, learning robust models from few and noisy samples, and DNA data storage. We are seeking a researcher to join our team in a DFG funded project on deep...


  • Munich, Deutschland Technical University of Munich Vollzeit

    PhD positions on Foundation Models and Deep Learning for Imaging Problems 19.04., Wissenschaftliches Personal The Professorship of Machine Learning at the Department of Computer Engineering at TUM has open positions for a doctoral researcher (TV-L E13 %, 3-4 years) on Foundation Models and/or Deep Learning for Imaging Problems. The...


  • Munich, Deutschland Technische Universität München Vollzeit

    Description: DNA methylation is an important epigenetic modification with fundamental roles in gene regulation and transposable element silencing. In plants, aberrant DNA methylation changes (i.e. epimutations) can arise stochastically, similar to DNA sequence mutations. These epimutations are often transmitted across generations and accumulate in plant...


  • Munich, Deutschland Technical University of Munich Vollzeit

    Software engineering PhD position in the area Software&Systems Engineering – Fuzzing for Software Security (TV-L E13, %) 24.01., Wissenschaftliches Personal The chair of software and systems engineering (SSE) has an open position (starting as soon as possible) for a PhD student with skills in the areas of “Fuzzing for software security.”...


  • Munich, Deutschland Technical University of Munich Vollzeit

    Software engineering PhD position in the area Software&Systems Engineering – CPS / Testing Autonomous Vehicles (TV-L E13, %) 24.01., Wissenschaftliches Personal The chair of software and systems engineering (SSE) has an open position (starting as soon as possible) for a PhD student with skills in the areas of Cyber-Physical Systems/Testing...


  • Munich, Deutschland Max-Planck-Institut für Quantenoptik Vollzeit

    We offer positions to PhD and Diploma/Master students with exceptional CV. They should be among the 5% top students in their university and have some extraordinary achievements (like, e.g., in physics/mathematics olympiads). For the Diploma/Master students we can only offer financial help if they have carried out their studies outside the Munich area. The...


  • Munich, Deutschland Technical University of Munich Vollzeit

    Software engineering PhD position in the area Software&Systems Engineering - Generative AI for Code Migration (TV-L E13, %) 24.01., Wissenschaftliches Personal The chair of software and systems engineering (SSE) has an open position (starting as soon as possible) for a PhD student with skills in the area of Using generative AI for code...


  • Munich, Deutschland Technical University of Munich Vollzeit

    PhD Position in Natural Language Processing für Dialogsysteme 05.03., Wissenschaftliches Personal Der Lehrstuhl Software Engineering for Business Information Systems (sebis) an der Technischen Universität München sucht herausragende Kandidaten für eine voll finanzierte Doktorandenstelle im Bereich der natürlichen Sprachverarbeitung...

  • Phd Student

    vor 4 Wochen


    Munich, Deutschland Deutsches Zentrum für Neurodegenerative Erkrankungen Vollzeit

    **PhD student (f/m/x)**: **Code: 2096/2023/1**: The research group “Juvenile Neurodegeneration”, led by Dr. Sabina Tahirovic, is looking for a PhD student with a strong interest in neuroinflammation and neurodegeneration. **Your tasks**: **Requirements**: **We offer**: - An interesting and challenging research question in a comprehensive scientific...

  • Phd Student

    Vor 5 Tagen


    Munich, Deutschland Klinikum rechts der Isar der Technischen Universität München Vollzeit

    **Hospital rechts der Isar (MRI) of Munich Technical University (TUM)** **PhD student** - Immunology** **Full-time or Part-time | temporary contract | Neurologische Klinik und **Institut für Experimentelle Neuroimmunologie** **Your responsibilities**: - explore the identity, regulation and relevance of regulatory T cells in the post-inflammatory central...


  • Munich, Deutschland Technische Universität München Vollzeit

    **The research group Cyber-Physical Systems of Prof. Matthias Althoff at the Technical University of Munich offers a PhD position in the area of learning-based model predictive control with formal guarantees. The Technical University of Munich is one of the top research universities in Europe fostering a strong entrepreneurial spirit and international...


  • Munich, Deutschland Technische Universität München Vollzeit

    The position is paid according to the German public salary scale TVL-13 and provides a competitive salary with standard benefits. The initial appointment is for a period of two years and can be renewed for another two years. Applications will be reviewed on a rolling basis. Susanne Albers Department of Computer Science Technical University...

  • Phd Position

    Vor 5 Tagen


    Munich, Deutschland Technische Universität München Vollzeit

    **Job description** This fully-funded PhD project (project P02 of the CRC1371) is based on work from the first funding period that identified the X-linked inhibitor of apoptosis protein (XIAP) as an important regulator of small-intestinal homeostasis. XIAP functions as an inhibitor of microbiota, TNF-, and RIPK3-dependent death of Paneth cells and myeloid...


  • Munich, Deutschland Deutsches Krebsforschungszentrum Vollzeit

    **Position**:PhD Student in Cancer Evolution** **Department**: DKTK partner site Munich, Department of Medicine III (University Hospital of Munich, LMU, Spiekermann lab) and the Core Facility "Mouse Models of Acute Leukemias" (HMGU / Jeremias lab) **Code number**:2023-0058 The German Cancer Research Center is the largest biomedical research institution in...

  • PhD student

    vor 1 Woche


    Munich, Deutschland Technical University of Munich Vollzeit

    PhD student 06.05., Wissenschaftliches Personal The Leibniz Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM) is a research institution of the Leibniz Association is looking for a PhD student in the working group "Molecular Modeling" to start on 01/07/. The Leibniz Institute for Food Systems...