Phd Student

vor 1 Monat


Freiburg, Deutschland Universitätsklinikum Freiburg Vollzeit

The research group of Prof. Dr. Georg Häcker at the Institute of Medical Microbiology and Hygiene offers the position of a

**PhD student (M/F/d)**:

- We work on a number of aspects of the response of human cells to infection, with a particular focus on the apoptosis apparatus. Most pathogens in fact do not induce apoptosis. Instead, they activate the apoptotic pathway to a low level that stays ‘sub-lethal’. We believe that this activation is important for pathogen recognition. One effect of this sub-lethal signaling is the introduction of damage to the genomic DNA, and we and others have found that the signals can introduce mutations, which may predispose to cancer.- This project will follow up on this line of research. It will analyze DNA-damage induced by a number of pathogens and mediators. It will measure the consequences of these signals for tumour evolution and mechanisms of secondary mutations. We will use models of cell lines, primary cells and organoids to understand these mechanisms.**We offer**:
- a very well-equipped laboratory with colleagues skilled in many methods of basic medical research
- good opportunities for scientific exchange and interaction
- work in a pleasant atmosphere in a laboratory of 10-15 colleagues**Your tasks**:

- to use a broad portfolio of methods and further to develop novel scientific approaches
- some work with agents of infectious disease
- interactions with bioinformaticians with regard to mutational analysis

**Your profile**:

- a MSc. in cell biology, cellular microbiology, immunology or similar fields
- a technical background in cell biology/ molecular biology
- English language skills
- The position is limited to 3 years.**University Medical Center Freiburg**
- Institute of Medical Microbiology and Hygiene**Prof. Dr. Georg Häcker**
- Hermann-Herder-Str. 11, 79104 Freiburg



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