Scientific/principal Investigator

**Site Name**: UK - Hertfordshire - Stevenage, Cambridge 300 Technology Square, Heidelberg - Office, USA - Pennsylvania - Upper Providence
**Posted Date**: Nov 20 2024

**Scientific/Principal Investigator, Genomic Technologies, Human Genetics and **Genomics**

This position may be based at a GSK R&D site in UK (Stevenage), in USA (Cambridge Tech Square, MA; or Upper Providence, PA), or in Germany (Heidelberg).

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage _Life at GSK | GSK_

We are seeking an innovative scientist to join our team as either Scientific or Principal Investigator in _Genomic Technologies_. Within the Human Genetics and Genomics (HGG) department at GSK, the _Genomic Technologies _group integrates deep and broad expertise in computational and statistical methods and techniques, to enable best-in-class analytical insight and interpretation of genetics and genomics data, impacting GSK drug discovery and development portfolio and pipeline decisions.
- Discovery of new causal gene-phenotype links through analysis of large-scale individual level human genetic data and GWAS/xQTL summary statistics.

**Responsibilities**:

- Generating large-scale analysis outputs, and/or implementing state-of-the-art tools for dynamically analysing, interpreting, and visualizing genetic and genomic data.
- Evaluating, improving, testing, and developing production implementations of best-in-class methods for analysis of genetics and genomics data, in collaboration with scientists in Data and Predictive Sciences, Biostatistics, or/and AI/ML teams.
- Collaborating with partners in applied and translational teams across HGG, in experimental Target Discovery, and in GSK disease area Research Units, to influence portfolio and pipeline decisions.
- Contributing to a culture of innovation, quality, and willingness to learn and improve.

**_ Why _**_you?_**

***Required Qualifications & **Skills**:

- Advanced degree (PhD or equivalent) in a relevant scientific discipline.
- Excellent programming skills in R or python, and knowledge of techniques in reproducible research, literate programming, FAIR data principles, or software development.
- Experience of evaluating, improving, testing, and/or developing statistical methods for analysis and interpretation of large-scale genetics or genomics data.
- Experience with genetic, genomic, epigenomic, or experimental/functional genomic data, and with state-of-the-art methods for data analysis and interpretation.
- Strong communication and team-working skills.

**Preferred Skills & **Experience**:

- Experience with machine learning and/or advanced statistical methods.
- Experience working in multidisciplinary teams on complex and impactful projects.
- Experience with integrating information across multiple genetic, genomic, epigenomic, or experimental/functional genomic data types.
- Experience with analysis of very large datasets using distributed or cloud computing technologies (e.g. SQL, PySpark, BigQuery, Docker, Nextflow).

**Closing Date for Applications - 4th December 2024 (COB)**

Please take a copy of the Job Description, as this will not be available post closure of the advert.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We’re uniting science, technology and talent to get ahead of disease together.

Find out more:
Our approach to R&D.

**Why GSK?**

**Uniting science, technology and talent to get ahead of disease together.**

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and o