Phd Position

vor 3 Monaten

Hamburg, Deutschland Leibniz-Institut für Virologie Vollzeit

The Leibniz Institute of Virology (LIV) is an independent research institution for basic biomedical research. As a foundation under civil law and member of the Leibniz Association, the Institute occupies a leading position both nationally and internationally.
The BMBF research group, headed by Dr. Ulrike Lange, focuses on the biology of human exogenous and endogenous retroviruses and on development of approaches to control retroviral infections. The group uses a wide range of experimental methods combined with computation biology approaches to address research questions that span from basic to translational science. We have recently generated advanced AAV gene therapy vectors for primary lymphocytes using a nanobody engineering approach (Hamann et al., 2021, PLoS ONE). We are now expanding this work with the aim of developing optimized engineered AAV-based vectors for HIV-1-targeted in vivo gene therapy. The PhD position will be focused on this project, which will be carried out in context of a collaborative research effort with Yale University and Gladstone Institutes (Capsid-engineered AAV vectors with Brec1-based gene therapeutics for inactivating the HIV reservoir NIH R01AI181053).
PhD position (f/m/x)
AAV Engineering for HIV-1 Targeted Gene Therapy
Your tasks
- Conduct an experimental research project on the topic of HIV-1 targeted gene therapy
- Present research findings at regular internal meetings as well as national and international conferences
- Collaborate with project research partners and national and international colleagues
- Develop as independent researcher with accountability towards the research project and group

**Profile**:

- Strong commitment, team spirit, very good communication and organizational skills, and ability to plan and execute experiments in an independent and flexible manner
- Very good English language skills (oral and written)
- Previous laboratory experiences in molecular biology and cell culture techniques
- Expertise in AAV technology and/or primary immune cell culture is an asset
- Open for research stays abroad for example at institutions of collaborating partners according to needs of project

What we offer
- Working as part of a highly motivated team in an international environment
- Remuneration according to EG 13 TV-AVH (Hamburg Employment Law Association Collective Agreement) (comparable to TVöD - Civil Service Collective Agreement), including company pension scheme
- 30 days of annual vacation
- Further training opportunities, incl. subsidized English and German courses at the Institute
- Health protection offers at the Institute (in cooperation with voiio GmbH)
- Flexible, family-friendly working hours
- HVV Deutschlandticket subsidy
- Canteen use subsidy

The position is initially limited for 3 years with start date of 1st January 2025.
The LIV is certified with the Total Equality distinction, and promotes work-life balance and professional equality between women and men. Women/men are therefore particularly encouraged to apply. Severely disabled persons will be given preferential consideration if their suitability, qualifications, and professional performance are otherwise equal.
**Contact**:
Leibniz Institute of Virology (LIV) | Martinistraße 52 (N63) | 20251 Hamburg |

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